疑难病杂志2023，Vol.22Issue(12)：1233-1237,5.DOI:10.3969/j.issn.1671-6450.2023.12.001
血清PKM2与PCT联合对脓毒症患者的诊断价值研究
Study on the diagnostic value of serum PKM2 combined with PCT in sepsis patients
摘要
Abstract
Objective To explore the diagnostic value of serum pyruvate kinase M2(PKM2)and procalcitonin(PCT)in sepsis.Methods One hundred and nineteen sepsis patients(sepsis group)admitted to the Intensive Care Unit(ICU)of Wuhan University People's Hospital from April 2022 to January 2023,and 73 non sepsis patients(non sepsis group)admitted to the ICU during the same period were selected as the study subjects.Detect and compare the serum lev-els of PKM2 and PCT in two groups of patients within 24 hours of admission,and use Spearman correlation test to analyze the correlation between serum PKM2 and PCT levels in sepsis patients;Using a multivariate logistic regression model to an-alyze the impact of various indicators on the occurrence of sepsis;Draw a receiver operating characteristic(ROC)curve to evaluate the diagnostic value of serum PKM2,PCT,and their combination in sepsis,and calculate the area under the curve(AUC).Results Compared with the non sepsis group,the serum PKM2 and PCT levels in the sepsis group were signifi-cantly increased(Z/P=9.373/＜0.001,9.013/＜0.001).There is a positive correlation between serum PKM2 and PCT levels in sepsis patients(r=0.322,P＜0.001).Multivariate logistic regression analysis showed that elevated levels of serum PKM2 and PCT were independent risk factors for sepsis occurrence[OR(95％CI)=1.182(1.078-1295),1582(1.186-2.110)].The ROC curve shows that the AUC of serum PKM2,PCT,and their combination for diagnosing sepsis were 0.903,0.888,and 0.941,respectively,with sensitivity of 0.863,0.918,and 0.932,and specificity of 0.798,0.748,and 0.857,respectively.The com-bined diagnostic efficacy of the two was higher than that of individual detection(Z/P=2.560/0.011,3.423/＜0.001).Conclu-sion The elevated serum PKM2 level in patients with sepsis is an independent risk factor for sepsis and is positively cor-related with PCT.Combined detection of the two has high diagnostic value.关键词
脓毒症/丙酮酸激酶M2/降钙素原/诊断Key words
Sepsis/Pyruvate kinase M2/Procalcitonin/Diagnosis分类
医药卫生引用本文复制引用
王历,彭适,蔡馨,汤冬玲,张平安..血清PKM2与PCT联合对脓毒症患者的诊断价值研究[J].疑难病杂志,2023,22(12):1233-1237,5.基金项目
国家自然科学基金资助项目(81773444) （81773444）
湖北省卫健委面上科研项目(WJ2023M073)National Natural Science Foundation of China(81773444) （WJ2023M073）
Hubei Provincial Health Commission Natural Project(WJ2023M073) （WJ2023M073）
