疑难病杂志2023，Vol.22Issue(12)：1238-1244,7.DOI:10.3969/j.issn.1671-6450.2023.12.002
脓毒症相关急性肾损伤患者血清Galectin-1、Galectin-3水平变化及其与院内死亡的关系
Changes in serum Galectin-1 and Galectin-3 levels in patients with sepsis related acute kidney injury and their relationship with in-hospital mortality
摘要
Abstract
Objective To investigate the changes in serum Gal-1 and Gal-3 levels in patients with sepsis associat-ed acute kidney injury(SA-AKI)of different severity levels and their relationship with in-hospital mortality.Methods Two hundred and forty-three patients with sepsis admitted to the Intensive Care Department of Linfen Central Hospital in Shanxi Province from January 2020 to January 2023 were included,including 123 SA-AKI patients as the SA-AKI group and 120 patients with simple sepsis as the simple sepsis group.Patients in the SA-AKI group were divided into stage 1 subgroup(48 cases),stage 2 subgroup(43 cases),and stage 3 subgroup(32 cases)based on acute kidney injury(AKI)staging,and were divided into death subgroup and survival subgroup according to their in-hospital outcomes.Enzyme linked immu-nosorbent assay was used to detect serum Gal-1 and Gal-3 levels.Analyze the influencing factors of in-hospital mortality in SA-AKI patients through multiple logistic regression analysis.The predictive value of receiver operating characteristic(ROC)curve analysis of serum Gal-1 and Gal-3 levels on the risk of in-hospital mortality in SA-AKI patients.Results Compared with the simple sepsis group,the serum Gal-1 and Gal-3 levels in the SA-AKI group increased(t/P=34.417/＜0.001,15 207/＜0.001).The serum Gal-1 and Gal-3 levels in the 1st,2nd,and 3rd subgroups increased sequentially(F/P=302.934/＜0.001,51.068/＜0.001).Univariate analysis showed that age,AKI stage,use of vasoactive drugs,mechanical ventilation,acute physiological and chronic health assessment Ⅱ(APACHE Ⅱ)scores,blood lactate,Gal-1,and Gal-3 were the influencing fac-tors for in-hospital mortality in SA-AKI patients(x2/t=3.514,43.619,7.041,8.483,4.563,4.081,10282,6.335,P＜0.05 or 0.01).Multivariate logistic regression analysis showed that age ≥ 60 years,AKI stage 2-3,mechanical ventilation and APACHE Ⅱscore,elevated blood lactate,Gal-1,and Gal-3 levels were independent risk factors for in-hospital mortality in SA-AKI pa-tients[OR(95％CI)=1.683(1.145-2.476),2.710(1.107-6.633),3.670(1.398-9.631),1.548(1.070-2.240),1.532(1.123-2.093),1.438(1.042-1.984)1.040(1.016-1.065),1.192(1.071-1.327),P＜0.05 or 0.01].ROC curve analysis showed that the area under the curve(AUC)for predicting in-hospital mortality in SA-AKI patients was 0.720(0.454-0.960),0.771(0.558-0.971),and 0.830(0.686-0.967)for serum Gal-1 and Gal-3 levels alone and in combination,respectively.The combined pre-dictive value of the two indicators was greater than that of each indicator alone(Z=2.652,2.968,P=0.008,0.003).Conclu-sion The elevated levels of serum Gal-1 and Gal-3 are closely related to the worsening of the condition and in-hospital mortality in SA-AKI patients.The combined detection of serum Gal-1 and Gal-3 levels has a high predictive value for in-hospital mortality in SA-AKI patients.关键词
脓毒症/急性肾损伤/半乳糖凝集素-1/半乳糖凝集素-3/病情程度/预后Key words
Sepsis/Acute kidney injury/Galectin-1/Galectin-3/Severity of illness/Prognosis分类
医药卫生引用本文复制引用
冯亚,高春明,张耀军,陈自谦,祁夏夏,张梅荣,房云岗..脓毒症相关急性肾损伤患者血清Galectin-1、Galectin-3水平变化及其与院内死亡的关系[J].疑难病杂志,2023,22(12):1238-1244,7.基金项目
国家重点研发计划课题(2019YFC090834)National Key R&D Program Project(2019YFC090834) （2019YFC090834）
