疑难病杂志2023，Vol.22Issue(12)：1336-1339,4.DOI:10.3969/j.issn.1671-6450.2023.12.021
儿童噬血细胞综合征及血液净化技术治疗的研究进展
Research progress on blood purification technology in children with hemophagocytic syndrome
摘要
Abstract
Hemophagocytic lymphohistiocytosis is a syndrome of multiple organ system injury induced by hyper-cytokinemia and immune-mediated abnormal activation of immune cells.The application of chemo immunotherapy has effec-tively reduced the overall mortality rate,but the mortality rate of patients with early multiple organ dysfunction is still high.In recent years,the early application of blood purification has not only rapidly reduced immune inflammatory mediators,but also effectively protected and restored organ function,which has important clinical significance for improving the prognosis of patients.In the future,more clinical studies on large-scale blood purification therapy are needed to form standardized treatment plans,in order to maximize the benefits for patients.This article reviews the etiology,pathogenesis,and application of blood purification technology in recent years of HLH,in order to provide scientific reference for clinical diagnosis and treatment of HLH.关键词
噬血细胞淋巴组织细胞增生症/发病机制/血液净化/化学免疫疗法Key words
Hemophagocytic lymphohistiocytosis/Pathogenesis/Blood purification/Chemimmunotherapy分类
临床医学引用本文复制引用
罗南都,杜作晨,陈艳..儿童噬血细胞综合征及血液净化技术治疗的研究进展[J].疑难病杂志,2023,22(12):1336-1339,4.基金项目
贵州省科技计划项目(黔科合基础-ZK[2022]一般641)Guizhou Provincial Science and Technology Plan Project(ZK[2022]-641) （黔科合基础-ZK[2022]一般641）
