云南化工2023，Vol.50Issue(12)：25-29,5.DOI:10.3969/j.issn.1004-275X.2023.12.06
含酚酰腙类衍生物的合成及生物活性研究
Synthesis and Biological Evaluation of AcylhydrazoneDerivatives Containing Phenol Moieties
摘要
Abstract
Sixteen acylhydrazonederivatives containing phenol moieties(D1-D16)were obtained by using hydroxyl substituted methyl benzoates,hydrazine hydrate and hydroxy substituted benzaldehydes as raw materials through two step reaction of hydrazinolysis and condensation.Their structures were confirmed by 1 H NMR and 13 C NMR.The effects of the target compounds on tyrosinase and their antioxidant activities were test-ed.The preliminary test results showed that compounds D1,D8,D12 and D15 had a certain inhibitory effect on tyrosinase,while compounds D2 and D6 had a weak activation effect on tyrosinase.All the target compounds showed good ABTS free radicals scavenging activity,and the IC50 values were better than that of the positive controlascorbic acid.Some of the target compounds had excellent DPPH free radicals scavenging ac-tivity,which were significantly stronger than the positive controlascorbic acid.关键词
酪氨酸酶/抗氧化/合成/酚/酰腙Key words
tyrosinase/antioxidation/synthesis/phenol/acylhydrazone分类
化学化工引用本文复制引用
成玉洁,刘贞汝,谭志同,沈亚龙,王守信,盛筱..含酚酰腙类衍生物的合成及生物活性研究[J].云南化工,2023,50(12):25-29,5.基金项目
山东省医药卫生科技发展计划项目(202113050717) （202113050717）
济宁医学院大学生创新训练计划项目(cx2022115z). （cx2022115z）
