医学信息2023，Vol.36Issue(24)：42-45,4.DOI:10.3969/j.issn.1006-1959.2023.24.007
TIPE2、TNF-α、MMP-22在冠心病的表达和意义
Expression and Significance of TIPE2,TNF-α,MMP-22 in Coronary Heart Disease
摘要
Abstract
Objective To explore the expression level and clinical diagnostic value of serum TIPE2,TNF-α and MMP-22 in patients with coronary heart disease.Methods A total of 60 patients with coronary heart disease admitted to Changyi People's Hospital from January 2018 to December 2021 were included in the experimental group,and 60 healthy people in the same period were selected as the control group.The expression levels of serum TIPE2,TNF-α and MMP-22 were compared between the two groups,and their relationship with common clinical indicators was analyzed.Pearson correlation was used to analyze the relationship between TIPE2 and TNF-α and MMP-22.Results The expression level of serum TIPE2 in the experimental group was lower than that in the control group,while the expression levels of TNF-α and MMP-22 were higher than those in the control group(P＜0.05).The expression of TIPE2,TNF-α and MMP-22 was related to the degree of coronary artery stenosis and the duration of QRS wave.Pearson correlation analysis showed that TIPE2 expression was negatively correlated with TNF-α(r=-0.287,P=0.013)and MMP-22(r=-0.283,P=0.014).Conclusion The expression of TIPE2 in patients with coronary heart disease is decreased,while the expression of TNF-α and MMP-22 is increased,and the abnormal expression of TIPE2,TNF-α and MMP-22 is involved in the formation and development of coronary heart disease.关键词
TIPE2/TNF-α/MMP-22/冠心病Key words
TIPE2/TNF-α/MMP-22/Coronary heart disease分类
医药卫生引用本文复制引用
柳旭丽,徐红,刘金香,王志强..TIPE2、TNF-α、MMP-22在冠心病的表达和意义[J].医学信息,2023,36(24):42-45,4.基金项目
潍坊市卫生健康委科研项目(编号:WFWSJK-2022-155) （编号:WFWSJK-2022-155）
