摘要
Abstract
Objective To investigate the efficacy and safety of live combined bifidobacterium and lactobacillus combined with modified sequential therapy in the treatment of Hp positive chronic atrophic gastritis.Methods From March 2021 to March 2022,64 patients with Hp positive chronic atrophic gastritis diagnosed and treated by Guangxin District Center for Disease Control and Prevention and Guangxi District Traditional Chinese Medicine Hospital were selected as the research objects.They were divided into control group(n=32)and observation group(n=32)by random number table method.The control group was treated with modified sequential therapy,and the observation group was treated with live combined bifidobacterium and lactobacillus on the basis of modified sequential therapy.The clinical efficacy,Hp eradication rate,inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6),serum tumor necrosis factor-α(TNT-α)],gastric function indicators[serum motilin(MTL),gastrin(GAS),pepsinogen I(PG I)]and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75％,which was higher than 84.38％in the control group(P＜0.05).The eradication rate of Hp in the observation group was 90.63％,which was higher than 81.25％in the control group(P＜0.05).After treatment,the levels of CRP,IL-6 and TNT-α in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).After treatment,GAS and PG I in the two groups were higher than those before treatment,MTL was lower than that before treatment,and GAS and PG I in the observation group were higher than those in the control group,MTL was lower than that in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 6.25％,which was lower than 21.88％in the control group(P＜0.05).Conclusion For Patients with Hp positive chronic atrophic gastritis,live combined bifidobacterium and lactobacillus combined with modified sequential therapy is effective,which can improve the eradication rate of Hp,improve gastric function,inhibit the level of inflammatory factors,and the incidence of adverse reactions is low.关键词
双歧杆菌乳杆菌三联活菌/改良序贯疗法/慢性萎缩性胃炎/炎症因子Key words
BLive combined bifidobacterium and lactobacillus/Modified sequential therapy/Chronic atrophic gastritis/Inflammatory factor分类
医药卫生
