医学信息2023，Vol.36Issue(24)：76-79,4.DOI:10.3969/j.issn.1006-1959.2023.24.015
新活素联合地高辛治疗慢性心衰急性加重期的疗效分析
Curative Effect of rhBNP Combined with Digoxin in the Treatment of Acute Exacerbation of Chronic Heart Failure
摘要
Abstract
Objective To study the clinical efficacy of rhBNP combined with digoxin in the treatment of acute exacerbation of chronic heart failure(CHF).Methods Sixty patients with acute exacerbation of CHF admitted to Dingnan County First People's Hospital from January 2021 to December 2022 were included in the study.They were divided into control group and observation group by random number table method,with 30 patients in each group.The control group was treated with digoxin,and the observation group was treated with rhBNP combined with digoxin.The therapeutic effect,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)],24 h urine volume,urea nitrogen(BUN),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33％,which was higher than 76.67％in the control group(P＜0.05).After treatment,LVEF in the two groups was higher than that before treatment,LVEDV and LVESV were lower than those before treatment,and LVEF in the observation group was higher than that in the control group,LVEDV and LVESV were lower than those in the control group(P＜0.05).The 24 h urine volume of the two groups after treatment was greater than that before treatment,BUN was less than that before treatment,and the 24 h urine volume of the observation group was greater than that of the control group,BUN was less than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion rhBNP combined with digoxin is effective in the treatment of acute exacerbation of CHF,which can improve cardiac function,increase urine volume,reduce BUN level,and has high safety.关键词
慢性心衰/急性加重期/新活素/地高辛/心功能/尿素氮Key words
Chronic heart failure/Acute exacerbation period/rhBNP/Digoxin/Cardiac function/Urea nitrogen分类
医药卫生引用本文复制引用
龙海成,郭华,胡雪平..新活素联合地高辛治疗慢性心衰急性加重期的疗效分析[J].医学信息,2023,36(24):76-79,4.基金项目
赣州市科技计划项目(编号:20222ZDX7544) （编号:20222ZDX7544）
