摘要
Abstract
Objective To study the clinical efficacy of somatostatin and ulinastatin in the treatment of acute pancreatitis(AP)and its effect on gastrointestinal function.Methods A total of 72 patients with AP admitted to the Department of Emergency and Critical Care Medicine of Nanchang Third Hospital from October 2021 to October 2022 were selected and divided into control group(36 patients)and observation group(36 patients)according to the random number table method.The control group was treated with ulinastatin,and the observation group was treated with somatostatin and ulinastatin.The clinical efficacy,biochemical indexes[blood amylase(AMS),white blood cell(WBC),C-reactive protein(CRP)],bedside index of severity in acute pancreatitis(BISAP),gastrointestinal function score,recovery time(abdominal pain disappearance time,defecation time,AMS recovery time,hospitalization time)were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44％,which was higher than 77.78％in the control group(P＜0.05).After treatment,the levels of AMS,WBC and CRP in the two groups were lower than those before treatment,and the levels of AMS,WBC and CRP in the observation group were lower than those in the control group(P＜0.05).After treatment,the BISAP and gastrointestinal function scores of the two groups were lower than those before treatment,and the BISAP and gastrointestinal function scores of the observation group were lower than those of the control group(P＜0.05).The disappearance time of abdominal pain,defecation time,AMS recovery time and hospitalization time in the observation group were shorter than those in the control group(P＜0.05).Conclusion Somatostatin combined with ulinastatin is effective in the treatment of AP,which can effectively improve the patient's condition and gastrointestinal function,down-regulate the level of inflammatory injury markers in vivo,and accelerate its clinical recovery.关键词
急性胰腺炎/生长抑素/乌司他丁/胃肠功能/炎性因子Key words
Acute pancreatitis/Somatostatin/Ulinastatin/Gastrointestinal function/Inflammatory factors分类
临床医学
