摘要
Abstract
Objective To compare the brain protective effects of dexmedetomidine(Dex)and propofol(Pro)combined anesthesia in patients undergoing brain tumor resection.Methods A total of 86 patients who underwent brain tumor resection in our hospital from March 2017 to October 2022 were selected as the research objects.According to the random number table method,they were divided into Dex group(43 patients)and Pro group(43 patients).Dex group was treated with dexmedetomidine combined anesthesia,and Pro group was treated with propofol combined anesthesia.The hemodynamic indexes[mean arterial pressure(MAP),heart rate]of the two groups before anesthesia induction(T0),immediately after anesthesia induction(Tl),dural incision(T2),immediately after operation(T3)and 6 h after operation(T4)were compared.At the same time,the brain injury indexes[neuron-specific enolase(NSE),central nervous system specific protein(S-100β)]of patients at T0,T3,24 h after operation(T5)and 3 d after operation(T6)were monitored,and the onset time of anesthesia,recovery time,extubation time and adverse reactions of the two groups were counted.Results Compared with T0,the levels of HR and MAP at T1,T2 and T3 in the two groups were increased(P＜0.05).However,the levels of HR and MAP at T1,T2 and T3 in Dex group were lower than those in Pro group(P＜0.05).Compared with T0,the levels of NSE and S-100β at T3 and T5 in the two groups increased(P＜0.05),but the levels of NSE and S-100β at T3 and T5 in the Dex group were lower than those in the Pro group(P＜0.05).The onset time of anesthesia,recovery time and tracheal extubation time in the Dex group were shorter than those in the Pro group(P＜0.05).The incidence of anesthesia adverse reactions in the Dex group was lower than that in the Pro group(P＜0.05).Conclusion Dex combined anesthesia can reduce hemodynamic fluctuations and brain tissue damage in patients undergoing brain tumor resection.Meanwhile,its brain protection effect is better than that of Pro combined anesthesia,and the onset of anesthesia is faster and the recovery time is shorter.关键词
脑肿瘤切除手术/右美托咪定/异丙酚/脑保护/血流动力学Key words
Brain tumor resection surgery/Dextrmedetomidine/Propofol/Brain protection effect/Hemodynamics分类
临床医学
