空军军医大学学报2023，Vol.44Issue(12)：1133-1141,9.DOI:10.13276/j.issn.2097-1656.2023.12.001
手性药物不对称催化合成:机遇与挑战并存
Asymmetric catalytic synthesis of chiral drugs:opportunities and challenges
摘要
Abstract
Chirality is one of the fundamental attributes of nature,and chiral compounds are widely present in nature.The synthesis of chiral compounds,especially chiral drugs,has become a hot topic in scientific research and biopharmaceuticals.This paper focuses on the generation and evolution of enzyme catalysis,metal catalysis,and organic catalysis,as well as their importance,application range,limitations,and solutions in chiral drug synthesis.Besides,their development prospects are also discussed.Asymmetric catalytic reactions are the most economical,efficient and green method for preparing chiral drugs,in which catalyst plays an important role.In terms of chiral drug synthesis,while introducing the development status at home and abroad,this paper mainly describes dozens of new catalysts designed and synthesized by the author's team in the fields of metal catalysis and organic catalysis and their catalytic asymmetric reactions,and lists their applications in chiral drug synthesis.关键词
手性药物/不对称催化/金属催化/酶催化/有机催化Key words
chiral drugs/asymmetric catalysis/metal catalysis/enzyme catalysis/organic catalysis分类
医药卫生引用本文复制引用
张生勇,姜茹,何炜,王平安,聂慧芳,姚琳,张东旭..手性药物不对称催化合成:机遇与挑战并存[J].空军军医大学学报,2023,44(12):1133-1141,9.基金项目
国家自然科学基金(22108298,82102445) （22108298,82102445）
陕西省秦创原"科学家+工程师"队伍建设项目(2023KXJ-080) （2023KXJ-080）
陕西省手性药物工程技术研究中心项目(陕科计发[2011]251号) （陕科计发[2011]251号）
