空军军医大学学报2023，Vol.44Issue(12)：1219-1224,6.DOI:10.13276/j.issn.2097-1656.2023.12.014
原发胃弥漫大B细胞淋巴瘤的特点与预后研究
Characteristics and prognosis of primary gastric diffuse large B-cell lymphoma
摘要
Abstract
Objective To conduct a retrospective cohort study on the clinical and pathological features of primary gastric diffuse large B-cell lymphoma(PG-DLBCL)to probe into the clinical factors which affect the efficacy and prognosis,especially inflammatory and nutritional indicators.Methods PG-DLBCL patients treated in Xijing Hospital,Air Force Medical University from January 2010 to January 2021 were included,and the effects of pathological and clinical features on progression-free survival time(PFS)and overall survival(OS)were analyzed.Kaplan-Meier survival curve was used for univariate survival analysis,and Cox proportional hazard model was used for multivariate survival analysis.Results A total of 84 PG-DLBCL patients were included in this study,whose median PFS was 39.5 months,5-year PFS rate was 59.6％,median OS was 48 months,and 10-year OS rate was 70.1％.Univariate survival analysis showed that the prognostic factors of PFS in PG-DLBCL patients included pathological classification,gross type,number of extra-lymph node lesions,Ann Arbor staging,Lugano staging,performance status(PS)score,international prognostic index(IPI)score,serum lactate dehydrogenase(LDH),β2-microglobulin(β2-MG),derived neutrophil/lymphocyte ratio(dNLR),systemic inflammatory response index(SIRI),β2 microglobulin/lymphocyte ratio(βLR),lactate dehydrogenase/lymphocyte ratio(LLR),and prognostic nutritional index(PNI).The prognostic factors of OS included gross type,number of extra-lymph node lesions,Lugano staging,Ann Arbor staging,PS score,IPI score,LDH,lymphocyte/monocyte ratio(LMR),SIRI,βLR,LLR,PNI and controlling nutritional status(CONUT)score.Multivariate survival analysis showed that the independent risk factors of PFS included Lugano staging,PS score,IPI score,elevated β2-MG and SIRI,while the independent risk factors of OS included Lugano stage,PS score,IPI score and SIRI.Conclusion Lugano staging can better predict the prognosis of PG-DLBCL patients,and chemotherapy should be the main treatment.dNLR,LMR,SIRI,PNI,βLR,LLR and CONUT score are simple and meaningful prognostic indicators of inflammation and nutrition in PG-DLBCL patients,among which SIRI has higher predictive value and may be a new prognostic indicator.关键词
弥漫大B细胞淋巴瘤/原发胃淋巴瘤/炎性指标/系统炎症反应指数Key words
diffuse large B-cell lymphoma/primary gastric lymphoma/inflammatory index/systemic inflammatory response index分类
医药卫生引用本文复制引用
王世雄,唐海龙,张涛,高广勋,王哲,张娜,梁蓉,吕垚,王健红,段晓晖,吴振天,王冰璇,刘静,贾卫静,冯娟..原发胃弥漫大B细胞淋巴瘤的特点与预后研究[J].空军军医大学学报,2023,44(12):1219-1224,6.基金项目
国家自然科学基金青年科学基金(82100172) （82100172）
