医药导报2023，Vol.42Issue(12)：1802-1807,6.DOI:10.3870/j.issn.1004-0781.2023.12.010
罗沙司他对血液透析患者血脂代谢的调节作用
Regulation Effect of Roxadustat on Blood Lipid Metabolism in Hemodialysis Patients
摘要
Abstract
Objective To observe the regulatory effect of roxadustat on lipid metabolism while correcting anemia in hemodialysis patients.Methods Sixty patients with chronic kidney disease(CKD)receiving hemodialysis treatment at Nanjing Drum Tower Hospital and combined with concurrent renal anemia were selected.These included 30 patients receiving erythropoietin(EPO)therapy at a dose of 10 000 U per week,and 30 patients receiving roxadustat treatment at a dose based on body weight.The patients'hemoglobin levels were measured,and data on lipid and iron metabolism-related indicators were collected for statistical analysis.Results After 6 months of treatment,the mean hemoglobin levels of both groups of patients were significantly higher than the baseline levels.The mean hemoglobin level in the roxadustat group was higher than that in the EPO group(114.1±7.88 vs.122.23±10.33,P<0.05),but there was no significant difference in the achievement rate between the two groups(77%vs.93%,P>0.05).The total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and triglycerides(TG)in the roxadustat group decreased significantly(P<0.05),while there was no significant change in the EPO group.Compared with the EPO group,roxadustat showed an improvement in iron metabolism indicators.Conclusion Roxadustat has been shown to improve lipid metabolism while correcting anemia.关键词
罗沙司他/肾性贫血/血脂代谢Key words
Roxadustat/Renal anemia/Blood lipid metabolism分类
医药卫生引用本文复制引用
刘紫秋,杨婷,曹馨瑞,王路路,葛卫红..罗沙司他对血液透析患者血脂代谢的调节作用[J].医药导报,2023,42(12):1802-1807,6.基金项目
江苏省研究型医院学会精益化用药科研基金资助项目(JY202013) （JY202013）
中国药学会全国医药信息网2022科普研究重点项目基金资助项目(CMEI2022KPYJ00201). （CMEI2022KPYJ00201）
