医药导报2023，Vol.42Issue(12)：1850-1855,6.DOI:10.3870/j.issn.1004-0781.2023.12.018
两个厂家注射用盐酸万古霉素有效性和安全性及经济性的真实世界研究
Real-world Study on the Efficacy,Safety and Economics of Vancomycin Hydrochloride for Injection from Two Manufacturers
张海霞 1陈杏凯 1梁培 1刘金春 1李一辰 1刘梦颖 1汪思亮 1朱怀军 1葛卫红1
作者信息
- 1. 南京大学医学院附属鼓楼医院药学部,南京 210008||南京临床药学中心,南京 210008
- 折叠
摘要
Abstract
Objective To evaluate the differences in efficacy,safety and economics of vancomycin hydrochloride for injection between two manufacturers based on real-world data.Methods A total of 6 757 cases of intravenous use of vancomycin hydrochloride for injection from different manufacturers between January 1,2013 and December 31,2019 in the Affiliated Drum Tower Hospital of Nanjing University Medical School were retrospectively analyzed,and 5308 cases were matched by 1∶1 propensity score method,including 2 654 cases in the group A(domestic drug group)and 2 654 cases in group B(the innovator drug group).The differences in efficacy and safety between the two groups were compared.Cost-effectiveness analysis was used to compare the drug economics of the two groups.Results There were no significant differences in clinical cure rate,bacterial clearance rate,and incidence of adverse events between the two groups(P>0.05).In terms of economics,the average cost of vancomycin per capita,average daily cost of vancomycin and average cost of antibiotics per capita were significantly different between the two groups(P<0.05),and the cost of group B was higher than that of group A.Conclusion The efficacy and safety of vancomycin hydrochloride for injection were consistent between the two manufacturers.关键词
万古霉素/真实世界研究/一致性评价/倾向性评分匹配法Key words
Vancomycin/Real-world study/Consistency evaluation/Propensity score matching method分类
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张海霞,陈杏凯,梁培,刘金春,李一辰,刘梦颖,汪思亮,朱怀军,葛卫红..两个厂家注射用盐酸万古霉素有效性和安全性及经济性的真实世界研究[J].医药导报,2023,42(12):1850-1855,6.
