湖北医药学院学报2023，Vol.42Issue(6)：584-589,601,封3,8.DOI:10.13819/j.issn.2096-708X.2023.06.002
PRR11和SKA2在卵巢上皮性恶性肿瘤中的表达及预后相关性分析
Expression and Prognostic Correlation Analysis of PRR11 and SKA2 in Ovarian Epithelial Malignancies
摘要
Abstract
Objective To explore the relationship between proline-rich protein 11(PRR11),spindle and kinetochore-asso-ciated protein 2(SKA2)and the clinicopathology and prognosis of ovarian epithelial malignant tumors.Methods GEPIA database,LinkedOmics database and Kaplan-Meier Plotter database were used to study the expression and prognostic value of PRR11 and SKA2 in ovarian malignant tumors.The expressions of PRR11 and SKA2 in 15 cases of ovarian benign tissue and 50 cases of ovarian epithelial malignant tumor were detected by immunohistochemistry,and analyze the relationship be-tween the two and the clinical pathology of ovarian epithelial malignancy was analyzed.Results GEPIA database analysis results showed that compared with normal ovarian tissue,the expressions of PRR11 and SKA2 in ovarian malignant tumor were significantly increased(P＜0.05),and there was a correlation between them(P＜0.05).The LinkedOmics database a-nalysis showed that the differentially expressed gene(PRR11)was correlated with SKA2 in the ovarian malignant tumor co-hort.Kaplan-Meier Plotter database analysis results showed that the expression of PRR11 and SKA2 was associated with the Overall surviva rate(OS)of patients,and the overall survival rate of patients with high expression of PRR11 or SKA2 was lower than that of patients with low expression of PRR11 or SKA2 in ovarian tumor tissues(P＜0.001).However,the expression of PRR11 was not related to the progression-free survival(PFS)in patients(P＞0.05),while the expression of SKA2 was associated with PFS in patients(P＜0.05).The positive expression rate of PRR11 in ovarian epithelial malignant tumor and ovarian benign tissue was 84.00%(42/50)and 46.00%(7/15),respectively.The positive expression rates of SKA2 in ovarian epithelial malignant tumor and ovarian benign tissue were 92.00%(46/50)and 40.00%(6/15),respec-tively.The positive expression rates of PRR11 and SKA2 in ovarian epithelial malignant tumor were significantly higher than those in ovarian benign tissue,and the difference was statistically significant(P＜0.05).The expression differences of PRR11 and SKA2 in different FIGO stages of serous ovarian malignant tumors were statistically significant(P＜0.05),indi-cating that the high expression of PRR11 and SKA2 may lead to increased malignancy and the ability of invasive metastasis of ovarian serous malignant tumors.There was no statistical significance in expression levels among age,vascular nerve in-filtration and lymphatic metastasis(P＞0.05).Spearman correlation analysis showed that PRR11 and SKA2 were positively correlated in epithelial ovarian tumors(r=0.475,P＜0.05),and were positively correlated in serous tumors and borderline tumors(r=0.516,P＜0.05 in serous tumors;r=0.459,P＜0.05 in borderline tumors).Conclusion PRR11 and SKA2 are highly expressed in ovarian malignant tumors,and their expression levels are correlated with pathological types.The com-bined detection of PRR11 and SKA2 may have certain guiding significance for evaluating the malignancy of malignant tumors derived from ovarian epithelial tumors.关键词
卵巢上皮性恶性肿瘤/PRR11/SKA2/相关性Key words
Epithelial malignant tumor of ovary/PRR11/SKA2/Correlation引用本文复制引用
昌牧雨,张毅..PRR11和SKA2在卵巢上皮性恶性肿瘤中的表达及预后相关性分析[J].湖北医药学院学报,2023,42(6):584-589,601,封3,8.基金项目
十堰市科技局项目(21Y52) （21Y52）
