诊断学理论与实践2023，Vol.22Issue(4)：341-347,7.DOI:10.16150/j.1671-2870.2023.04.003
出凝血检测在肿瘤患者中的应用价值探讨
The application value of determination of hemostasis and thrombosis in tumor patients
摘要
Abstract
Abnormal coagulation function is an important feature of the occurrence and development of malignant tumors.Tumor cclls release pro-angiogenic factors that cause vascular endothelial damage and induce platelet activation and proliferation,all of which increase the risk of thrombosis.Cancer patients often present with shortened APTT and PT,elevated fibrinogen,D-dimer and platelet counts,and a hypercoagulable state.With thrombosis forms,the fibrinolytic sys-tem is activated,and D-dimer and fibrin degradation product(FDP)increase.Both are commonly used markers of the fibri-nolytic system.FDP/D-dimer ratio may improve the accuracy of diagnosing thrombosis or bleeding.New coagulation mark-ers,such as platelet function and platelet surface markers,can be used to assess platelet activation.During the hypercoagu-lable state and the fibrinolysis process of tumors,four new thrombosis factors are discovered:thrombin-antithrombin(TAT),plasmin a2-plasmin inhibitor complex(PIC),tissue plasminogen activator-inhibitor 1 complex(t-PAIC)and thrombomodu-lin,which can be used as diagnostic markers for malignant tumors and thrombosis.Thromboelastography simultaneously re-flects coagulation factor activity,fibrinogen activity,platelet counts and function,and demonstrates the overall dynamic pro-cess of coagulation and fibrinolysis.The 6 traditional coagulation tests combined with platelet count,the 4 new thrombosis tests combined with D-dimer and FDP tests,as well as various thrombosis risk assessment models,play an important role in the prognosis assessment of different tumors.With the development of artificial intelligence and new indicators,the applica-tion prospects of coagulation abnormality detection will be broader.关键词
出凝血检测/肿瘤/临床应用Key words
Hemostasis and thrombosis determination/Tumor/Clinical application分类
医药卫生引用本文复制引用
王砚春,卢仁泉..出凝血检测在肿瘤患者中的应用价值探讨[J].诊断学理论与实践,2023,22(4):341-347,7.基金项目
国家自然科学基金面上项目(82072876) （82072876）
