中国病理生理杂志2023，Vol.39Issue(12)：2288-2295,8.DOI:10.3969/j.issn.1000-4718.2023.12.021
1-磷酸鞘氨醇调控血管功能在动脉粥样硬化中的研究进展
Progress in regulation of vascular function by sphingosine-1-phosphate in atherosclerosis
摘要
Abstract
Sphingosine-1-phosphate(S1P)is a bioactive lipid that regulates a variety of physiological processes,including immune surveillance,immune cell transport,vascular development,and cell differentiation.S1P also plays an important role in regulating vascular function and balancing endothelial barrier homeostasis.The majority of S1P mole-cules are located in their chaperone proteins,such as apolipoprotein M or albumin.The chaperone protein is also a carrier and modulator of S1P molecules,and the combination of the two can protect the S1P structure.S1P-binding chaperone pro-tein selectively activates S1P receptor in the form of a complex that opens downstream pathways by coupling with different S1P receptor targets to exert its effects in vivo.The present review elucidates the metabolism and function of S1P,as well as the effect of chaperones on its function,and clarifies the regulation of S1P in vascular activity and pathogenesis of atherosclerosis.关键词
1-磷酸鞘氨醇/载脂蛋白M/白蛋白/血管功能/内皮细胞屏障/动脉粥样硬化Key words
sphingosine-1-phosphate/apolipoprotein M/albumin/vascular function/endothelial barrier/atherosclerosis分类
基础医学引用本文复制引用
吴婧,施媛萍..1-磷酸鞘氨醇调控血管功能在动脉粥样硬化中的研究进展[J].中国病理生理杂志,2023,39(12):2288-2295,8.基金项目
分子发育生物学国家重点实验室开放课题(No.2022-MDB-KF-17) （No.2022-MDB-KF-17）
常州市国际科技合作计划(No.CZ20220024) （No.CZ20220024）
常州市"十四五"卫生健康高层次人才培养工程拔尖人才(No.2022260) （No.2022260）
