中国肺癌杂志2023，Vol.26Issue(12)：943-949,7.DOI:10.3779/j.issn.1009-3419.2023.101.34
肺癌发生发展的遗传多样性选择假说
Hypothesis of Genetic Diversity Selection in the Occurrence and Development of Lung Cancer:Molecular Evolution and Clinical Significance
刘宝东1
作者信息
- 1. 100053 北京,首都医科大学宣武医院胸外科
- 折叠
摘要
Abstract
So far,the monoclonal hypothesis of tumor occurrence and development cannot be justified.The ge-netic diversity selection hypothesis for the occurrence and development of lung cancer links Mendelian genetics with Darwin's theory of evolution,suggesting that the genetic diversity of tumor cell populations with polyclonal origins-monoclonal selec-tion-subclonal expansion is the result of selection pressure.Normal cells acquire mutations in oncogenic driver genes and have a selective advantage over other cells,becoming tumor initiating cells;In the interaction with the tumor microenvironment(TME),the vast majority of initiating cells are recognized and killed by the human immune system.If immune escape occurs,the incidence of malignant tumors will greatly increase,and subclonal expansion,intratumour heterogeneity,etc.will occur.This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance.关键词
肺肿瘤/遗传多样性/选择/分子进化/临床意义Key words
Lung neoplasms/Genetic diversity/Selection/Molecular evolution/Clinical significance引用本文复制引用
刘宝东..肺癌发生发展的遗传多样性选择假说[J].中国肺癌杂志,2023,26(12):943-949,7.
