中国防痨杂志2024，Vol.46Issue(1)：8-17,10.DOI:10.19982/j.issn.1000-6621.20230271
抗结核药物所致QTc间期延长临床监测和管理专家共识
Expert consensus on clinical monitoring and management of QTc interval prolongation caused by anti-tuberculous drugs
摘要
Abstract
Bedaquiline,delamanid,clofazimine and fluoroquinolones such as levofloxacin and moxifloxacin are essential to improve the global cure rate of multidrug resistant and extensively drug-resistant tuberculosis.However,these drugs may lead to the prolongation of QTc interval corrected by electrocardiograph,which may cause serious adverse effects.Clinicians need to timely find,properly deal with and prevent adverse effects.This article aims at the common problems in clinical monitoring and management of QTc interval prolongation caused by anti-tuberculous drugs.According to the published research data and the application experience of participating experts,it was formed through discussion among many experts.Professional advice was given on the discovery,treatment and prevention of QTc interval prolongation caused by anti-tuberculous drugs,aiming at timely and standardized prevention and treatment of adverse reactions in the process of anti-tuberculous treatment.关键词
抗结核药/心电描记术/QT延长综合征/药物毒性/病人医护管理Key words
Antitubercular agents/Electrocardiography/Long QT syndrome/Drug toxicity/Patient care management分类
医药卫生引用本文复制引用
中国防痨协会,《中国防痨杂志》编辑委员会,首都医科大学附属北京胸科医院,初乃惠,聂文娟..抗结核药物所致QTc间期延长临床监测和管理专家共识[J].中国防痨杂志,2024,46(1):8-17,10.基金项目
The"Sailing"Program for Clinical Medical Development(ZLRK202331) （ZLRK202331）
National Natural Science Foundation Project(82100002)临床医学发展专项"扬帆"计划项目(ZLRK202331) （82100002）
国家自然科学基金(82100002) （82100002）
