中国防痨杂志2024，Vol.46Issue(1)：54-61,8.DOI:10.19982/j.issn.1000-6621.20230261
上海市普陀区病原学阳性敏感肺结核患者家庭内密切接触者结核感染筛查情况及发病影响因素分析
Screening of latent tuberculosis infection and analysis of morbidity influencing factors in household contacts of positive and sensitive pulmonary tuberculosis patients in Putuo District,Shanghai
摘要
Abstract
Objective:To analysed the screening of latent tuberculosis infection(LTBI)and the morbidity influencing factors in household contacts of positive and sensitive pulmonary tuberculosis(PTB)patients in Putuo District,Shanghai.Methods:This was a prospective study,the study subjects were the household contacts of positive and sensitive PTB patients who tested for Mycobacterium tuberculosis infection by y-interferon release test in Putuo District from 2018 to 2021.After the first screen,the household contacts were followed up and tested for LTBI voluntarily within 3,6,12 months to calculate the cumulative infection rate.Binary logistic regression were used to analyze the risk factors of index cases on the LTBI of household contacts.The new cases were identified through the Tuberculosis Registration and Reporting System and short-term(end 202-12-03)incidence density of TB in household contacts were calculated.Results:From 2018 to 2021,a total of 168 PTB cases and 284 household contacts were enrolled in the study.The infection rate of the first screening test was 26.8％(76/284)and the cumulative infection rate was 34.5％(98/284)within one year.The results of multivariate analysis showed that the positive 2-month sputum examination of index cases was a risk factor for LTBI in household contacts(OR=7.167,95％CI:2.399-26.587,P=0.001).The short-term incidence density of 284 household contacts was 6.94/1000 person-years with 720.17 observation person-years.Five new cases were detected among and the short-term incidence density was 6.94/1000 person-years(5/720.17 person-years).There were no significant difference in the incidence density of PTB between LTBI household contacts(15.76/1000 person-years(4/253.83 person-years))and non-infected individuals(2.14/1000 person-years(1/466.34 person-years))(x2=2.607,P=0.106).Conclusion:The infection risk was high in household contacts of PTB patients.Index cases with positive 2-month sputum examination result had higher risks of generating LTBI.The timely diagnosis and effective treatment of smear-positive household contacts should be strengthened to effectively prevent the spread of tuberculosis in household contacts.关键词
结核,肺/潜伏性结核病/家庭/接触者追踪/多相筛查/流行病学研究Key words
Tuberculosis,pulmonary/Latent tuberculosis/Family/Contact tracing/Multiphasic screening/Epidemiologic studies分类
医药卫生引用本文复制引用
孙嘉轩,刘艳,梁鹏飞,郑亦慧,胡屹,陈静,徐飚..上海市普陀区病原学阳性敏感肺结核患者家庭内密切接触者结核感染筛查情况及发病影响因素分析[J].中国防痨杂志,2024,46(1):54-61,8.基金项目
Major Scientific and Technological Project of"Prevention and Treatment of Major Infectious Diseases such as AIDS and Viral Hepatitis"(2018ZX10715012)"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项——上海市大城市结核病综合防治模式研究(2018ZX10715012) （2018ZX10715012）
