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湖南省细菌耐药监测网2012-2021年铜绿假单胞菌耐药性监测报告

刘健龙宁兴旺石国民邬靖敏杨怀德袁红霞郑铭黄勋吴安华任南宋春荣付敏胡琼陈丽华付陈超李晨李艳明刘君

中国感染控制杂志2023，Vol.22Issue(12)：1452-1459,8.

中国感染控制杂志2023，Vol.22Issue(12)：1452-1459,8.DOI:10.12138/j.issn.1671-9638.20233827

湖南省细菌耐药监测网2012-2021年铜绿假单胞菌耐药性监测报告

Antimicrobial resistance of Pseudomonas aeruginosa:surveillance report from Hunan Provincial Antimicrobial Resistance Surveillance System,2012-2021

刘健龙 ¹宁兴旺 ²石国民 ³邬靖敏 ⁴杨怀德 ⁵袁红霞 ⁶郑铭 ⁷黄勋 ⁸吴安华 ⁸任南 ⁹宋春荣 ¹付敏 ¹胡琼 ¹陈丽华 ¹⁰付陈超 ⁷李晨 ¹¹李艳明 ¹²刘君¹³

作者信息

1. 湖南省儿童医院检验中心,湖南长沙 410007
2. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410007
3. 长沙市中心医院检验科,湖南长沙 410004
4. 长沙市第一医院检验科,湖南长沙 410005
5. 张家界市人民医院检验科,湖南张家界 427000
6. 郴州市第一人民医院检验医学中心,湖南郴州 423000
7. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008
8. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008
9. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008
10. 中南大学湘雅三医院检验科,湖南长沙 410013
11. 浏阳市中医医院检验科,湖南浏阳 410300
12. 中南大学湘雅医院检验科,湖南长沙 410008
13. 湘潭市中心医院检验科,湖南湘潭 411100
折叠

摘要

Abstract

Objective To understand the distribution and changes in antimicrobial resistance of clinically isolated Pseudomonas aeruginosa(P.aeruginosa)in the member hospitals of Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021.Methods Antimicrobial susceptibility testing by disk diffusion or automa-ted instrument was performed on clinical isolates.Testing results were determined according to the standards of 2022 edition from American Clinical Laboratory Standards Institute(CLSI).Statistical analysis was performed by WHONET 5.6 software.Data were analyzed by trend test(Cochran-armitage)and Chi-square test with SPSS.Results A total of 176 441 strains of P.aeruginosa were surveilled by Hunan Provincial Antimicrobial Resistance Surveillance System from 2012 to 2021.99.4％of the strains were isolated from hospitalized patients,and about 70％of the strains were isolated from respiratory specimens.8.4％of P.aeruginosa were from children(0-17 years old),91.6％were from adults.Antimicrobial susceptibility testing results showed that P.aeruginosa was most sensitive to polymyxin B over 10 years,with a resis-tance rate of less than 6％.Resistance rates to piperacil-lin,piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,imipenem,amikacin,gentamicin,tobramycin,cip-rofloxacin,levofloxacin,and polymyxin B all showed downward trends.A total of 29 920 carbapenem-resistant P.aeruginosa(CRPA)strains were detected.The average isolation rate of CRPA in this province was 18.0％over 10 years.CRPA detection rate from adult was 18.5％,higher than that from children(12.3％),and both showing downward trends.Conclusion The resistance rate of clinically isolated P.aeruginosa in Hunan Province to most commonly used antimicrobial agents is decreasing.

关键词

细菌/抗菌药物/铜绿假单胞菌/耐药性/监测/湖南省细菌耐药监测网

Key words

bacteria/antimicrobial agent/Pseudomonas aeruginosa/antimicrobial resistance/surveillance/Hu-nan Provincial Antimicrobial Resistance Surveillance System

分类

医药卫生

引用本文复制引用

刘健龙,宁兴旺,石国民,邬靖敏,杨怀德,袁红霞,郑铭,黄勋,吴安华,任南,宋春荣,付敏,胡琼,陈丽华,付陈超,李晨,李艳明,刘君..湖南省细菌耐药监测网2012-2021年铜绿假单胞菌耐药性监测报告[J].中国感染控制杂志,2023,22(12):1452-1459,8.

基金项目

湖南省自然科学基金项目(NO01JJY2119) （NO01JJY2119）

湖南省自然科学基金-科卫联合项目(2023JJ60011) （2023JJ60011）

"感·动中国"医疗机构感染预防与控制科研项目(GY2023013-A) （GY2023013-A）

中国感染控制杂志

OA北大核心CSCDCSTPCD

ISSN：1671-9638

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