中国临床药理学与治疗学2023，Vol.28Issue(12)：1357-1364,8.DOI:10.12092/j.issn.1009-2501.2023.12.005
姜黄素对长期高盐诱导高血压大鼠中枢的作用机制
Central mechanism of curcumin on the paraventricular hypothalamic nucleus of high salt induced hypertension rats
摘要
Abstract
AIM:To assess the effect of curcumin in hypothalamic paraventricular nucleus(PVN)and mean arterial pressure so as to explore the central mechanism of hypertension.METHODS:Sixty Sprague-Dawley rats which body weights between 170 and 190 grams fed with a normal salt(0.3％Na-Cl)or a high salt(8％NaCl)diet for 6 weeks.Mean-while half of each team received curcumin adminis-tration or vehicle by intragastric administration.Mean Arterial pressure was measured noninvasive-ly via tail-cuff instrument and their recording sys-tem.The PVN tissue samPles were collected and stored at-80 ℃ for later analyses.We performed the following experimental procedures:Western blot analysis,immunofluorescence,immunofluores-cence and statistical analysis.RESULTS:The aver-age arterial blood Pressure of rats in the high-salt diet group was significantly reduced after 6 weeks of curcumin intervention.The levels of NOX2,NOX4,TLR4,MyD88,IL-6,IL-1β,MCP-1 and ROS in the long-term high-salt diet grouP were significant-ly higher after curcumin intervention.CONCLU-SION:Curcumin can improve blood pressure in hy-pertensive rats induced by long-term high salt,the mechanism may be related to the improvement of oxidative stress and inflammatory cytokines in the paraventricular nucleus of the hypothalamus.关键词
高血压/姜黄素/高盐饮食/下丘脑室旁核Key words
hypertension/curcumin/high salt in-take/hypothalamic paraventricular nucleus分类
医药卫生引用本文复制引用
孟婷婷,高红丽,高祎凡,张清岚,于晓静..姜黄素对长期高盐诱导高血压大鼠中枢的作用机制[J].中国临床药理学与治疗学,2023,28(12):1357-1364,8.基金项目
陕西省自然科学基础研究计划(2021JQ-068) （2021JQ-068）
2023年陕西省大学生创新创业训练计划项目 （）
