中国临床医学2023，Vol.30Issue(6)：919-926,8.DOI:10.12025/j.issn.1008-6358.2023.20231232
非透析慢性肾脏病患者sST2、NT-proBNP、hs-cTnT与左心室构型的相关性
Correlations between sST2,NT-proBNP,hs-cTnT and left ventricular geometry in patients with chronic kidney disease
摘要
Abstract
Objective To investigate the associations between soluble growth stimulation expressed gene 2 protein(sST2),conventional biomarkers and left ventricular geometry in patients with chronic kidney disease(CKD).Methods Patients with non-dialysis-dependent CKD in Department of Nephrology,Zhongshan Hospital,Fudan University were enrolled from August 2019 to December 2020.Clinical data were collected,and serum sST2,N-terminal pro-B-type natriuretic peptide(NT-proBNP)and high-sensitivity cardiac troponin T(hs-cTnT)were measured.Left ventricular structure was assessed by transthoracic echocardiography.Left ventricular geometric patterns were defined according to left ventricular mass index(LVMI)and relative wall thickness(RWT).Differences of cardiac biomarkers between different left ventricle geometric groups were analyzed with Tukey's post-hoc test.Multiple linear regression models were used to evaluate the correlations between biomarkers and cardiac structure parameters.Results A total of 652 patients with CKD were enrolled,and the detection rate of LVH was 33.4%.The detection rate of LVH increased as kidney function worsened,with 64.3%in CKD G5 patients.Compared with normal geometry group,NT-proBNP and hs-cTnT levels elevated in both concentric LVH(cLVH)and eccentric LVH(eLVH)patients(P＜0.001),while sST2 level only elevated in the cLVH patients(P=0.025).Multiple linear regression analysis showed that sST2 was associated with LAD and LVMI(P＜0.01);NT-proBNP was associated with left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),posterior wall thickness(PWT),interventricular septum thickness(IVST),left ventricular ejection fraction(LVEF),left ventricular mass(LVM),and LVMI(P＜0.000 1);hs-cTnT was associated with LAD,PWT,IVST,LVM,RWT and LVMI(P＜0.01).Conclusions sST2 could increase in CKD patients with cLVH,while has not significant change in eLVH patients,which is different from NT-proBNP and hs-cTnT.关键词
可溶性生长刺激表达基因2蛋白/白介素33/慢性肾脏病/左心室肥厚/左心室几何构型Key words
soluble growth stimulation expressed gene 2 protein/interleukin-33/chronic kidney disease/left ventricular hypertrophy/left ventricular geometry分类
医药卫生引用本文复制引用
林琳,林雪萍,沈波,石一沁,张臻,滕杰..非透析慢性肾脏病患者sST2、NT-proBNP、hs-cTnT与左心室构型的相关性[J].中国临床医学,2023,30(6):919-926,8.基金项目
福建省2023年省级临床重点专科建设项目,厦门市科技计划指导性项目(3502Z20214ZD1068).Supported by Fujian Provincial Key Clinical Specialty in 2023,Guiding Project of Xiamen Scientific and Technological Plan(3502Z20214ZD1068). （3502Z20214ZD1068）
