中国临床医学2023，Vol.30Issue(6)：981-987,7.DOI:10.12025/j.issn.1008-6358.2023.20231669
地西他滨联合非血缘脐血移植治疗缓解后老年急性髓系白血病的疗效和安全性
Efficacy and safety of decitabine combined with unrelated umbilical cord blood transplantation in the elderly patients with acute myeloid leukemia after achieving remission
摘要
Abstract
Objective To compare the safety and efficacy of decitabine combined with unrelated umbilical cord blood transplantation and traditional regimen in the elderly patients with acute myeloid leukemia(AML)after achieving complete remission with induction therapy.Methods Fifty-two elderly AML patients who obtained complete remission(CR)after 1-2 cycles of induction therapy in the Department of Hematology of Yancheng First People's Hospital and the Huai'an First Hospital Affiliated to Nanjing Medical University from January 2019 to January 2022 were enrolled,and were divided into the observation group(n=24)and the control group(n=28).The observation group received decitabine combined with unrelated umbilical cord blood transplantation,and the control group received traditional consolidation therapy,including azacitidine+vinblastine,idarubicin+cytarabine(IA),or aclarubicin+cytarabine+granulocyte colony-stimulating factor,and so on.The hematopoietic recovery time,adverse reactions,relapse-free survival(RFS),and overall survival(OS)were compared between the two groups.Results The median recovery time of neutrophils was 12.54 d in the observation group and wes 18.64 d in the control group(P＜0.001);the median recovery time of platelets was 12.67 d in the observation group and was 19.71 d in the control group(P＜0.001).There was no difference in incidences of grade Ⅲ-Ⅳ myelosuppression and non-hematological toxicity between the two groups.There were statistical differences in the median RFS(33 months vs 11 months)and OS(36 months vs 24 months)between the observation group and the control group(P＜0.05).Conclusions Compared with the traditional consolidation regimen,decitabine combined with unrelated umbilical cord blood transplantation for consolidation of AML after achieving remission is more effective in elderly patients,could prolong survival,and has similar safety.关键词
非血缘脐血移植/巩固治疗/老年/急性髓系白血病/疗效/安全性Key words
unrelated umbilica cord blood transplantation/consolidation therapy/the elderly/acute myeloid leukemia/efficacy/safety分类
医药卫生引用本文复制引用
陈璨,黄永芬,王玲玲,马亚男,程月新,徐浩,陶善东,苗雨青..地西他滨联合非血缘脐血移植治疗缓解后老年急性髓系白血病的疗效和安全性[J].中国临床医学,2023,30(6):981-987,7.基金项目
盐城市医学科技发展计划项目(YK2020004、YK2020014).Supported by Medical Science and Technology Development Project of Yancheng(YK2020004,YK2020014). （YK2020004、YK2020014）
