中国临床医学2023，Vol.30Issue(6)：1027-1032,6.DOI:10.12025/j.issn.1008-6358.2023.20231618
m6A甲基转移酶样3基因在泛癌中的表达及对肿瘤微环境的影响
Expression of m6A methyltransferase like 3 in pan-tumor and its effect on tumor microenvironment
摘要
Abstract
Objective To analyze the expression of m6A methyltransferase like 3(METTL3)gene in pan-tumor and its effect on tumor microenvironment.Methods The Cancer Genome Atlas(TCGA)database was used to analyze the gene sequencing and clinical data of patients with various tumors.The expressions of METTL3 gene in various tumors and its correlations with prognosis and tumor microenvironment were analyzed.Results METTL3 gene expression was upregulated in most malignancies,but only was associated with poor PFS of patients with hepatocellular carcinoma and prostate cancer(P＜0.05).The expression of METTL3 gene was associated with the infiltration levels of many inmmunet cells in hepatocellular carcinoma and prostate cancer,as well as the expression levels of inhibitory immune checkpoint genes(P＜0.05).Conclusions METTL3 gene overexpression could affect the prognosis of hepatocellular carcinoma and prostate cancer,which maybe associated with immune invasion and inhibitory immune checkpoints increased.关键词
m6A甲基转移酶样3/生物信息学/泛癌/肿瘤微环境/免疫浸润Key words
m6A methyltransferase like 3/bioinformatics/pan-tumor/tumor microenvironment/immune infiltration分类
临床医学引用本文复制引用
费夏玮,张菊根,戴黎阳,吴振启,沈彦婷,李慧峰..m6A甲基转移酶样3基因在泛癌中的表达及对肿瘤微环境的影响[J].中国临床医学,2023,30(6):1027-1032,6.基金项目
国家自然科学基金(62101319),上海市青浦区科技发展基金研究项目(QKY2020-23),上海市青浦区卫健委学科人才专项(YY2023-3).Supported by National Natural Science Foundation of China(62101319),Qingpu District Science and Technology Development Fund of Shanghai(QKY2020-23),Qingpu District Health Commission Discipline Talent Project of Shanghai(YY2023-3). （62101319）
