中国内镜杂志2023，Vol.29Issue(12)：59-64,6.DOI:10.12235/E20230001
高分化直肠神经内分泌肿瘤的临床病理特征及预后分析
Clinicopathological characteristics and prognosis of well-differentiated rectal neuroendocrine tumor
王鑫 1吴琼 1胡益民 1许秀丽 1王喆 1张海辉 2韩双印 2李修岭2
作者信息
- 1. 商丘市中心医院 消化科,河南 商丘 476000
- 2. 河南省人民医院 消化科,河南 郑州 450003
- 折叠
摘要
Abstract
Objective To investigate the clinicopathological characteristics and prognosis of well-differentiated rectal neuroendocrine tumor(RNET).Methods A retrospective analysis was conducted using the clinical data from 83 patients with well-differentiated RNET from August 2017 to December 2021,including clinical manifestations,endoscopy,endoscopic treatment,postoperative complications,postoperative pathology,follow-up and prognosis.Pathological results according to the 2019 World Health Organization(WHO)Classification of digestive system tumors,83 patients were divided into G1 stage group(72 cases)and G2 stage group(11 cases);Based on the number of tumors in the patient,83 patients were divided into two groups:single RNET group(77 cases)and multiple RNET group(6 cases),the expressions of chromogranin A(CgA),synapsin(Syn)and CD56 were compared among different groups.Results Based on pathological findings in the group,G1 stage group CgA positive rate was significantly higher than that of G2 stage group,the difference was statistically significant(χ2 = 4.23,P = 0.040);Based on the number of tumors,multiple RNET group CgA positive rate was significantly higher than that of single RNET group,the difference was statistically significant(χ2 = 5.74,P = 0.017).It was no significant difference in Syn and CD56 between the two groups(P＞0.050).Conclusion Well-differentiated RNET has no specific clinical manifestations.It is mostly isolated in G1 stage and single RNET.ESD is safe and has a good prognosis,the positive rate of CgA is higher in G1 stage patients,and the positive rate of CgA is higher in patients with multiple RNET.关键词
高分化/直肠神经内分泌肿瘤(RNET)/临床病理特征/嗜铬粒蛋白A(CgA)/预后Key words
well-differentiated/rectal neuroendocrine tumor(RNET)/clinicopathological characteristics/chromogranin A(CgA)/prognosis分类
临床医学引用本文复制引用
王鑫,吴琼,胡益民,许秀丽,王喆,张海辉,韩双印,李修岭..高分化直肠神经内分泌肿瘤的临床病理特征及预后分析[J].中国内镜杂志,2023,29(12):59-64,6.
