中国普通外科杂志2023，Vol.32Issue(11)：1629-1638,10.DOI:10.7659/j.issn.1005-6947.2023.11.001
三阴性乳腺癌精准治疗研究进展
Advances in precision treatment of triple-negative breast cancer
邵笛 1余天剑 1邵志敏1
作者信息
- 1. 复旦大学附属肿瘤医院 乳腺外科/复旦大学上海医学院 肿瘤学系,上海 200032
- 折叠
摘要
Abstract
With the flourishing development of omics technologies in recent years,the widespread application of genomics,transcriptomics,metabolomics,modification-specific proteomics,single-cell transcriptomics,spatial transcriptomics,and other omics approaches has deepened the multidimensional analysis of triple-negative breast cancer(TNBC)heterogeneity.The in-depth exploration in basic research has made it possible to target some key signaling pathways for precision therapy.Recent clinical studies have discovered promising therapeutic approaches,offering therapeutic opportunities for both early and late-stage TNBC patients by targeting tumor-intrinsic mechanisms and microenvironmental characteristics.Based on the intrinsic features of TNBC and the current treatment landscape,the authors of this article discuss the progress of precision therapy from the perspectives of internal heterogeneity and treatment modalities in TNBC.关键词
三阴性乳腺癌/分子分型/精准医学Key words
Triple Negative Breast Neoplasms/Molecular Subtypes/Precision Medicine分类
医药卫生引用本文复制引用
邵笛,余天剑,邵志敏..三阴性乳腺癌精准治疗研究进展[J].中国普通外科杂志,2023,32(11):1629-1638,10.
