中国人兽共患病学报2023，Vol.39Issue(11)：1060-1064,5.DOI:10.3969/j.issn.1002-2694.2023.00.124
2022年济南市3株输入性新型冠状病毒奥密克戎BQ.1全基因组特征分析
Genome-wide characterization of three imported strains of novel coronavirus Omicron BQ.1 in Jinan,2022
摘要
Abstract
This study was aimed at understanding the genome-wide characterization and variations for three imported novel coronavirus(SARS-CoV-2)strains from different sources in the same period in Jinan at the viral genome level,to provide a sci-entific basis for further improving the prevention and control of COVID-19 outbreaks at Jinan port.We selected nasal and pha-ryngeal swab samples from three cases of imported asymptomatic COVID-19infectionat Jinan port;performed second-genera-tion whole-genome sequencing;and analyzed the variant loci and homology withvarious bioinformatics software.The whole ge-nome sequence of SARS-CoV-2 was successfully obtained from three samples of asymptomatic infected cases,and had full lengths ranging from 29 835 bp to 29 844 bp.Pangolin typing results indicated that the genotypes of the three samples were O-micron BQ.1,BQ.1.1,and BQ.1.12.Compared with the original Wuhan strain,the three samples produced mutations at 77,80,and 78 base sites,respectively,involving 60-63 non-synonymous mutations,mainly in the S and ORF1ab genes.Omicron BQ.1 is an imported variant of the SARS-CoV-2 virus and was detected for the first time at Jinan port.From a molecular biolo-gy perspective,this study provides a theoretical basis for the source tracing and prevention and control of COVID-19 at theport.关键词
新型冠状病毒/境外输入/奥密克戎变异株/全基因组测序/进化分析Key words
SARS-CoV-2/overseas imported/Omicron variant/whole genome sequencing/evolutionary analysis分类
医药卫生引用本文复制引用
白飒,刘保华,闫荣军,赵辉,孙连波,张涛,韩焕美..2022年济南市3株输入性新型冠状病毒奥密克戎BQ.1全基因组特征分析[J].中国人兽共患病学报,2023,39(11):1060-1064,5.基金项目
山东省科技厅科研项目(No.2021CXGC 011306)、海关总署科研项目(No.2021HK139)、济南海关科研项目(No.2020JK003)Supported by the Scientific Research Project on Technology De-partment of Shandong Province(No.2021CXGC011306)and Re-search Project of General Administration of Customs(No.2021HK139)and Research Project of Jinan Customs(No.2020JK003) （No.2021CXGC 011306）
