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从代谢角度看冠状病毒与宿主的相互作用

黄梓鑫 周书亭 王哲

中国人兽共患病学报2023,Vol.39Issue(11):1072-1079,8.
中国人兽共患病学报2023,Vol.39Issue(11):1072-1079,8.DOI:10.3969/j.issn.1002-2694.2023.00.126

从代谢角度看冠状病毒与宿主的相互作用

The interaction between the coronavirus and the host from a metabolic point of view

黄梓鑫 1周书亭 1王哲1

作者信息

  • 1. 上海交通大学农业与生物学院动物科学系/上海市现代种业协同创新中心,上海 200240||上海市兽医生物技术重点实验室,上海 200240
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摘要

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)triggered the global pandemic of novel coronavirus pneumonia and brought the"coronavirus"into the public eye.It is well known that rapid replication of vi-ruses can cause drastic metabolism changes in host cell,and recent studies have found corresponding antiviral targets from these key changes.In this review,we focus on recent studies on the effects of coronavirus on host metabolism,including lipid metabolism,central carbon metabolism,amino acid metabolism etc.Identifying host cell metabolic induced viral infection not only helps to better understand virus-host interactions,but also helps to develop potential antiviral strategies by targeting meta-bolic alterations.

关键词

冠状病毒/细胞代谢/药物靶点

Key words

coronavirus/cellular metabolism/drug targets

分类

医药卫生

引用本文复制引用

黄梓鑫,周书亭,王哲..从代谢角度看冠状病毒与宿主的相互作用[J].中国人兽共患病学报,2023,39(11):1072-1079,8.

基金项目

Supported by the National Key Research and Development Plans of China(No.2021YFD1800400).Wang Zi-xin and Zhou Shu-ting contributed equally to this paper.国家重点研发计划资助项目(No.2021YFD1800400) (No.2021YFD1800400)

中国人兽共患病学报

OA北大核心CSCDCSTPCD

1002-2694

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