中国人兽共患病学报2023，Vol.39Issue(11)：1095-1099,5.DOI:10.3969/j.issn.1002-2694.2023.00.129
多房棘球蚴原头节感染后阻断PD-1对巨噬细胞吞噬功能的影响
Effects of PD-1 blockade on macrophage phagocytosis after Echinococcus multilocularis protoscoleces infection
摘要
Abstract
This study analyzed the changes in macrophage phagocytosis after Echinococcus multilocularis protoscoleces(PSC)infection.The distribution of macrophages in hepatic alveolar echinococcosis patients was analyzed by immunohisto-chemistry.PD-1 blockade,PSCs and macrophages were co-cultured to analyze macrophage phagocytosis and the expression lev-els of CD47 and PD-1.Macrophages labeled by CD68 aggregated in close live tissue from the lession of alveolar echinococcosis patients.PSC infection resulted in lower intensity of Escherichia coli and higher expression of CD47 and PD-1 than observed in the control group(P＜0.001).The intensity of Escherichia coli increasedin the PD-1 blockade group after PSC infection(q=40.63,P＜0.05).PD-1 blockade restored macrophage phagocytosis after PSC infection.关键词
多房棘球蚴原头节/程序性死亡分子1/巨噬细胞/吞噬功能Key words
Echinococcus multilocularis protoscoleces/Programmed death(PD-1)/macrophage/phagocytosis分类
医药卫生引用本文复制引用
张涛,张耀刚,杨紫晗,沈银红,马艳艳..多房棘球蚴原头节感染后阻断PD-1对巨噬细胞吞噬功能的影响[J].中国人兽共患病学报,2023,39(11):1095-1099,5.基金项目
Supported by the National Natural Science Foundation of China(No.82360128),Qinghai Department of Science and Technolo-gy Project(No.2021-SF-135),Young and middle-aged Scientific Research Fund of Qinghai University Affiliated Hospital(No.ASRF-2021-YB-02)and Qinghai Province"Kunlun Talents High-end innovative and entrepreneurial talents".国家自然科学基金(No.82360128) （No.82360128）
青海省科技厅项目(No.2021-SF-135) （No.2021-SF-135）
青海大学附属医院中青年科研基金一般项目(No.ASRF-2021-YB-02)和青海省"昆仑英才·高端创新创业人才"联合资助. （No.ASRF-2021-YB-02）
