中国人兽共患病学报2023，Vol.39Issue(11)：1124-1129,6.DOI:10.3969/j.issn.1002-2694.2023.00.134
宿主导向的抗结核药物靶点研究进展
Research progress in host-directed anti-tuberculosis drug targets
摘要
Abstract
Tuberculosis is a serious zoonotic disease causing approximately 10 million new cases worldwide every year.The emergence of various drug-resistant strains of Mycobacterium tuberculosis is currently an important challenge intuberculosispre-vention and control,and an urgent need exists to develop new anti-tuberculosis drugs to treat drug-resistant tuberculosis and shorten the treatment time.The discovery of drug targets is a bottleneck inthe development of new anti-tuberculosis drugs.At present,the widely reported drug targets for tuberculosis include primarily new targets related to the biosynthesis of Mycobac-terium tuberculosis components and immune metabolic pathways.In addition,host-directed therapiestargeting the host immune system have become a research hotspot in recent years.Adjuvant host-directed therapies can enhance the therapeutic effect of tuberculosis and shorten treatment times by affecting granuloma formation,autophagy,host immune metabolism and the intra-cellular killing mechanism,as well as regulating pulmonary inflammation.The discovery of these new targets provides new ide-as for the future development of safe and effective new anti-tuberculosis drugs.关键词
结核病/结核分枝杆菌/药物靶点/免疫代谢/宿主导向治疗Key words
tuberculosis/Mycobacterium tuberculosis/drug target/immune metabolism/host-directed therapies分类
医药卫生引用本文复制引用
郭雪颖,张志芳,万珈旭,高妍,陈祥,徐正中,焦新安..宿主导向的抗结核药物靶点研究进展[J].中国人兽共患病学报,2023,39(11):1124-1129,6.基金项目
国家重点研发计划项目(No.2021YFD1800403)、江苏省农业科技自主创新资金项目[No.CX(21)1004]、江苏省重点研发计划(现代农业)(No.BE2021331)、高等学校学科创新引智计划(No.D18007)和优势学科建设工程项目(PAPD)联合资助Supported by the National Key Research and Development Program of China(No.2021YFD1800403),the Agricultural Science and Technology Independent Innovation Fund Project of Jiangsu Province[No.CX(21)1004],the Key Research and Development Program(Modern Agriculture)Project of Jiangsu Province(No.BE2021331),the Program of introdu-cing talents through discipline Innovation in Colleges and U-niversities(No.D18007),and the Construction Project of Ad-vantageous Disciplines(PAPD). （No.2021YFD1800403）
