中国输血杂志2023，Vol.36Issue(12)：1089-1094,6.DOI:10.13303/j.cjbt.issn.1004-549x.2023.12.002
福州地区无偿献血人群新冠疫苗加强免疫与突破性感染后特异性抗体消长情况分析
Serological follow-up of anti-SARS-CoV-2 antibodies in blood donors after COVID-19 vaccine booster dose and breakthrough infections in Fuzhou
摘要
Abstract
Objective To analyze the dynamics of specific SARS-CoV-2 IgG antibodies in blood donors in Fuzhou area after receiving booster doses of inactivated COVID-19 vaccine and breakthrough infections,and to provide evidence for the timing of the collection of specific immune plasma or convalescent plasma and the subsequent vaccine doses.Methods A to-tal of 109 volunteers who received the first booster dose of inactivated COVID-19 vaccine and 102 volunteers who experienced breakthrough infections were recruited at Fujian Blood Center from October to November 2021.Blood samples were collected at eight time points:14(11,20)days before the booster dose(Time0),14(10,23)days after the booster dose(Time1),53(45.5,61)days after the booster dose(Time2),88(78,101.5)days after the booster dose(Time3),124(112.5,138.5)days after the booster dose(Time4),158(146,174)days after the booster dose(Time5),194(179.5,214)days after the booster dose(Time6)and within one month after the breakthrough infection(Time7).Serum SARS-CoV-2 IgG an-tibodies were detected using a chemiluminescence immunoassay.The dynamics of antibody levels were analyzed and the effects of age,gender,weight,BMI,blood type and smoking on antibody levels were also analyzed.Results The positive rate of SARS-CoV-2 IgG antibodies was 53.2%(58/109)at Time0,100%(109/109)at Time1,and 95.4%(104/109)at Time6.The antibody levels were significantly higher at Time1 and Time6 than at Time0(P＜0.001).The highest level was observed at Time1,followed by a gradual decrease until Time2-Time6,which were 89.9%(9.74/10.84),77.7%(8.42/10.84),68.3%(7.4/10.84),59.4%(6.44/10.84),and 53.9%(5.84/10.84)of the peak value at Time1(P＜0.001).There were no significant differences in IgG antibody levels among different gender,weight,BMI,age,blood type and smoker or non-smoker at the same time points(P values all＞0.05).The IgG antibody level at Time7 was 2.07 times than that at Time1(P＜0.001).There were no significant differences in IgG antibody levels between asymptomatic groups and symptomat-ic groups and also between fever-free groups and fever groups(P values all＞0.05).The IgG antibody level in breakthrough infection group was significantly higher than that in non-breakthrough infection group(P＜0.001).Conclusion Booster do-ses of inactivated COVID-19 vaccine and breakthrough infections can stimulate stronger immune responses in the body.It is rec-ommended to collect specific immune plasma or convalescent plasma within one month after breakthrough infections or booster doses of COVID-19 vaccine for special purposes.The timing of subsequent vaccine doses should be based on the dynamics of antibody levels.It is necessary to continuously monitor antibody levels to provide evidence for subsequent vaccine doses.关键词
新型冠状病毒/疫苗/抗体/突破性感染/福州Key words
novel coronavirus/vaccines/antibody/breakthrough infection/Fuzhou分类
医药卫生引用本文复制引用
纪淑华,林授,黄淑铭,林小枚,张宇,江伟梅,褚晓凌..福州地区无偿献血人群新冠疫苗加强免疫与突破性感染后特异性抗体消长情况分析[J].中国输血杂志,2023,36(12):1089-1094,6.基金项目
福建省科技厅社会发展引导性(重点)项目(2021Y0098) （重点）
