中国输血杂志2023，Vol.36Issue(12)：1098-1101,4.DOI:10.13303/j.cjbt.issn.1004-549x.2023.12.004
新冠疫情防控不同时期深圳地区无偿献血人群新冠病毒抗体检测结果
SARS-CoV-2 total antibody detection results in blood donors from Shenzhen during different periods of COVID-19 epidemic prevention and control
摘要
Abstract
Objective To analyze the SARS-CoV-2 detection results among blood donors in different periods of COVID-19 pandemic control in Shenzhen and assess the antibody levels and infection status of blood donors in different periods,so as to provide reference for subsequent blood testing strategies.Methods A total of 4 768 plasma samples of blood donors were subjected to pooled testing by nucleic acid testing(NAT)with 8 samples per pool.Additionally,these samples were subjec-ted to a 1000-fold dilution,and the detection of SARS-CoV-2 total antibody was performed by enzyme-linked immunosorbent assay(ELISA).The 4 768 plasma samples were collected from blood donors at different time points in Shenzhen,with in-quiries made to determine whether donors during the COVID-19 pandemic were in the convalescence.The antibody positive rates in blood screening samples during different periods of the pandemic and samples from individuals in the convalescence of COVID-19 infection were analyzed.Furthermore,the antibody levels were examined for differences based on gender,age,and blood type.Results All 4 768 plasma samples from blood donors were negative by NAT,while 2 342 samples were de-tected positive by the SARS-CoV-2 total antibody detection,with a positive rate of 49.1%.These samples from four periods(September 30 to October 3,2022;November 3 to 6,2022;December 27 to 31,2022;January 6 to 18,2023)were sub-jected to a 1 000-fold dilution for COVID-19 antibody detection,and the positive rates were 21.3%,15.8%,65.9%,and 93.9%,respectively.Conclusion The prevalence of COVID-19 antibodies among blood donors in Shenzhen during different periods of the pandemic varied significantly.There was no difference in antibody prevalence among different genders and blood types,while younger individuals exhibited a higher prevalence of antibodies.The risk of COVID-19 transmission through blood transfusion was found to be extremely low.关键词
新冠病毒/抗体检测/核酸检测/康复期献血者Key words
COVID-19/detection of SARS-CoV-2 antibody/nucleic acid testing(NAT)/convalescent blood donors分类
医药卫生引用本文复制引用
邬林枫,陈婷婷,王皓飚,刘衡,李彤,王立林,许晓绚,曾劲峰..新冠疫情防控不同时期深圳地区无偿献血人群新冠病毒抗体检测结果[J].中国输血杂志,2023,36(12):1098-1101,4.基金项目
深圳市医学重点学科建设项目(SZXK070) （SZXK070）
深圳市医疗卫生三名工程项目(SZSM201811092) （SZSM201811092）
深圳市血液中心科研课题(SZBC202318) （SZBC202318）
深圳市血液中心科研课题(SZBC202315) （SZBC202315）
