中国输血杂志2023，Vol.36Issue(12)：1132-1135,4.DOI:10.13303/j.cjbt.issn.1004-549x.2023.12.012
患者意外抗体的分布情况及其输血疗效分析
Distribution and transfusion efficacy of unexpected antibody
摘要
Abstract
Objective To investigate the clinical characteristics and antibody distribution as well as evaluate the transfu-sion efficacy in unexpected antibody positive patients.Methods A total of 12 235 patients from January 1,2022 to March 31,2023 who hospitalized in our hospital and applied for blood transfusion were selected,and those with unexpected antibod-y were included.The clinical data,including gender,age,diagnosis,blood type,history of transfusion and pregnancy were collected for antibody distribution analysis.Patients who received transfusion were grouped according to the DAT results and the components of red blood cells transfused,and the Hb values of each group before and after transfusion were compared.Results Among12 235 patients,118 were positive for antibody screening,with a prevalence of 0.96%.The antibodies from Rh system were the most common(27.43%,48/175),followed by MNS system(8.57%,15/175)and Lewis system(6.29%,11/175),mainly anti-E(18.29%,32/175),anti-M(8.00%,14/175)and anti-Lea(5.71%,10/175).In addi-tion,62 transfused patients were divided into group A with suspended red blood cell transfusion and group B with washed red blood cell transfusion for positive DAT,and group C for negative DAT.Hb values(g/L)pre-and post-transfusion were 59.19±15.67 vs 77.52±15.09 in group A,56.35±14.08 vs 74.44±15.63 in group B,56.00±12.06 vs 75.00±4.73 in group C,respectively.The Hb values of post-transfusion for three groups were all higher than those of pre-transfusion(P＜0.05).Con-clusion Anti-E from Rh system is the most common antibody in patients with unexpected antibody.Appropriate red blood cells transfusion with Hb increases by an average of 6-7 g/L per 1 U of red blood cells indicating good transfusion efficacy.For positive DAT patients,transfusion of suspended red blood cell is feasible.关键词
意外抗体/红细胞输注/疗效评价Key words
unexpected antibody/red blood cells transfusion/efficacy evaluation分类
医药卫生引用本文复制引用
章容,康凯,谢江,林雨薇,李族军,许基平,练正秋,李玲..患者意外抗体的分布情况及其输血疗效分析[J].中国输血杂志,2023,36(12):1132-1135,4.基金项目
中国医学科学院医学与健康科技创新工程(2021-1-I2M-060) （2021-1-I2M-060）
