中国现代医学杂志2023，Vol.33Issue(23)：10-15,6.DOI:10.3969/j.issn.1005-8982.2023.23.002
肺炎支原体肺炎合并哮喘患儿血清维生素D、CD5L、补体C3、IgE水平变化及与病情和炎症反应程度的关系
Changes of serum vitamin D,CD5L,complement C3 and IgE levels in children with MPP and asthma and their relationship with severity of illness and degree of inflammation
摘要
Abstract
Objective To explore the changes in serum levels of vitamin D,CD5 antigen-like protein(CD5L),complement C3,and immunoglobulin E(IgE)in children with Mycoplasma Pneumoniae Pneumonia(MPP)combined with asthma,and to investigate their clinical significance.Methods A retrospective study was conducted on 55 children diagnosed with MPP combined with bronchial asthma from January 2020 to June 2022 at Yangtze University Affiliated Jingzhou Hospital,designated as the observation group.Additionally,55 randomly selected MPP patients without bronchial asthma during the same period were selected as the control group.A comparison was made between the two groups in terms of vitamin D,CD5L,complement C3,complement C4,immunoglobulin G(IgG),immunoglobulin M(IgM),IgE,forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1),matrix metalloproteinase-2(MMP-2),and MMP-9.Results In the observation group,vitamin D and CD5L were lower,while complement C3,complement C4,IgG,IgM,IgE were higher compared to the control group(P＜0.05).FVC,FEV1,PEF were lower,and TNF-α,MMP-2,MMP-9 were higher in the observation group compared to the control group(P＜0.05).There was no statistically significant difference in TGF-β1 levels between the observation and control groups(P＞0.05).In the high-titer group,vitamin D was lower than in the low-titer group,and complement C3,IgG,IgM,IgE were higher than in the low-titer group(P＜0.05).No significant difference was observed between the high and low-titer groups in terms of CD5L and complement C4 levels(P＞0.05).Patients in the high-titer group had lower FVC,FEV1,PEF,and higher TNF-α,MMP-2,MMP-9 compared to the low-titer group(P＜0.05).There was no significant difference in TGF-β1 levels between the high and low-titer groups(P＞0.05).Pearson correlation analysis showed a negative correlation between serum vitamin D in MPP combined with asthma children and TNF-α,MMP-2,and MMP-9(r=-0.471,-0.663,and-0.682,respectively;all P＜0.05);CD5L showed a negative correlation with TNF-α,MMP-2,and MMP-9(r=-0.502,-0.610,and-0.634,respectively;all P＜0.05);TNF-α showed no correlation with complement C3,complement C4,IgG,IgM,IgE levels(r=0.201,0.114,0.238,0.217,0.226,respectively;all P＞0.05);TGF-β1 showed no correlation with vitamin D,CD5L,complement C3,complement C4,IgG,IgM,IgE levels(r=-0.083,-0.112,0.233,0.172,0.132,0.094,and 0.104,respectively;all P＞0.05);MMP-2 showed no correlation with complement C3,complement C4,IgG,IgM,IgE levels(r=0.182,0.158,0.192,0.216,and 0.171,respectively;all P＞0.05);MMP-9 showed no correlation with complement C3,complement C4,IgG,IgM,IgE levels(r=0.169,0.134,0.207,0.236,and 0.185,respectively;all P＞0.05).Conclusion Children with MPP combined with asthma have lower levels of vitamin D and CD5L and higher levels of complement C3 and IgE.These levels are associated with viral antibody titers and the degree of inflammatory response in children.关键词
肺炎支原体肺炎/哮喘/维生素D/CD5抗原样蛋白/补体C3/免疫球蛋白EKey words
mycoplasma pneumoniae pneumonia/asthma/vitamin d/CD5-like antigen protein/complement c3/immunoglobulin e分类
医药卫生引用本文复制引用
覃军,陈玲,邓蓉蓉,胡荆江..肺炎支原体肺炎合并哮喘患儿血清维生素D、CD5L、补体C3、IgE水平变化及与病情和炎症反应程度的关系[J].中国现代医学杂志,2023,33(23):10-15,6.基金项目
湖北省自然科学基金(No:2019CFB567) （No:2019CFB567）
