中国现代医学杂志2023，Vol.33Issue(23)：16-21,6.DOI:10.3969/j.issn.1005-8982.2023.23.003
血清嗜酸性粒细胞阳离子蛋白与白三烯B4联合预测支气管哮喘患儿预后的临床价值
Clinical value of serum eosinophil cationic protein and leukotriene B4 in predicting the prognosis of children with bronchial asthma
摘要
Abstract
Objective To investigate the clinical value of combined serum eosinophil cationic protein(ECP)and leukotriene B4(LTB4)in predicting the prognosis of pediatric asthma.Methods Eighty cases of pediatric asthma admitted to the Children's Hospital affiliated with Jiangnan University from December 2020 to December 2022 were selected for the study.Symptomatic treatment was given to the children,and after 28 days of treatment,the patients were divided into a well-controlled group and a poorly controlled group based on the improvement of pulmonary function indicators and the results of the Childhood Asthma Control Test(C-ACT).The serum levels of ECP and LTB4 were detected in both groups upon admission.A multifactorial Logistic stepwise regression model was used to analyze the risk factors affecting the disease control of pediatric asthma.Receiver Operating Characteristic(ROC)curves were drawn to evaluate the predictive efficacy of serum ECP and LTB4 for the prognosis of pediatric asthma.Results Among the 80 pediatric asthma patients,17 had poor control,while 63 had well-controlled conditions without relapse.The poorly controlled group had a higher proportion of allergic history,a history of recurrent respiratory infections,and higher levels of serum ECP and LTB4 than the well-controlled group(P＜0.05).Allergic history[OR=3.557(95％CI:1.053,12.023)],a history of recurrent respiratory infections[O(^)R=4.923(95％CI:1.289,18.806)],elevated serum ECP levels[O(^)R=3.770(95％CI:1.115,12.741)],and elevated serum LTB4 levels[OR=4.212(95％CI:1.246,14.236)]were all risk factors for poor disease control in pediatric asthma(P＜0.05).The sensitivity of serum ECP,LTB4,and their combination in predicting the prognosis of pediatric asthma was 73.6％(95％CI:0.619,0.842),77.1％(95％CI:0.625,0.891),and 88.5％(95％CI:0.703,0.951),respectively.The specificity was 80.3％(95％CI:0.724,0.875),66.9％(95％CI:0.603,0.749),and 76.4％(95％CI:0.631,0.872),respectively.The AUC was 0.786(95％CI:0.690,0.881),0.743(95％CI:0.644,0.843),and 0.834(95％CI:0.747,0.921),respectively.Conclusion Serum ECP and LTB4 are related to the prognosis of pediatric asthma.The predictive efficacy of serum ECP and LTB4,either alone or in combination,is good for predicting the prognosis of pediatric asthma.关键词
支气管哮喘/嗜酸性粒细胞阳离子蛋白/白三烯B4/预后Key words
asthma/eosinophil cationic protein/leukotriene b4/prognosis分类
医药卫生引用本文复制引用
孙果,徐洋,陈雨华,邵思超..血清嗜酸性粒细胞阳离子蛋白与白三烯B4联合预测支气管哮喘患儿预后的临床价值[J].中国现代医学杂志,2023,33(23):16-21,6.基金项目
江苏省基础研究计划(青年基金)项目(No:BK20210081) （青年基金）
