中国现代医学杂志2023，Vol.33Issue(23)：22-27,6.DOI:10.3969/j.issn.1005-8982.2023.23.004
FeNO、EOS与喘息性支气管炎患儿肺功能的相关性及对哮喘的预测价值
Correlation of FeNO and EOS with pulmonary function in children with asthmatic bronchitis and its predictive value for asthma
摘要
Abstract
Objective To explores the correlation between fractional exhaled nitric oxide(FeNO),peripheral blood eosinophils(EOS),and pulmonary function in children with wheezing bronchitis(WB)and their predictive value for asthma.Methods A retrospective analysis of medical records from 132 cases of wheezing bronchitis in children admitted to Wuhan First Hospital from June 2020 to June 2022 was conducted.Using the modified Asthma Predictive Index(mAPI)as a reference,the children were categorized into an asthma attack group(26 cases)and a wheezing bronchitis group(106 cases).Levels of FeNO,EOS,and pulmonary function indicators at admission were collected.Pearson's correlation analysis was employed to assess the correlation between FeNO,EOS,and pulmonary function in children with wheezing bronchitis.Receiver Operating Characteristic(ROC)curves were constructed to evaluate the predictive efficacy of FeNO and EOS for the development of asthma in children with wheezing bronchitis.Results FeNO and EOS levels were higher in the asthma attack group than in the wheezing bronchitis group(P＜0.05).Respiratory total resistance,central airway resistance,peripheral elastic resistance,and response frequency were all higher in the asthma attack group than in the wheezing bronchitis group(P＜0.05).In children with wheezing bronchitis,FeNO showed a positive correlation with respiratory total resistance(r=0.801,P=0.001),central airway resistance(r=0.648,P=0.001),peripheral elastic resistance(r=0.723,P=0.001),and response frequency(r=0.651,P=0.001).Similarly,EOS in children with wheezing bronchitis exhibited a positive correlation with respiratory total resistance(r=0.736,P=0.001),central airway resistance(r=0.612,P=0.001),peripheral elastic resistance(r=0.694,P=0.001),and response frequency(r=0.617,P=0.001).FeNO and EOS,both individually and in combination,demonstrated sensitivity of 65.4％(95％CI:0.443,0.821),69.2％(95％CI:0.481,0.849)and 78.9％(95％CI:0.579,0.914),and specificity of 71.7％(95％CI:0.619,0.798),79.8％(95％CI:0.652,0.856)and 73.6％(95％CI:0.639,0.814),respectively,for predicting the occurrence of asthma in children with wheezing bronchitis.The area under the ROC curve was 0.718(95％CI:0.603,0.858)for FeNO,0.729(95％CI:0.615,0.864)for EOS,and 0.816(95％CI:0.728,0.913)for their combination.Conclusion FeNO and EOS are positively correlated with respiratory total resistance,central airway resistance,peripheral elastic resistance,and response frequency in children with wheezing bronchitis,and they can be used to predict the occurrence of asthma.关键词
喘息性支气管炎/哮喘/呼出气一氧化氮/嗜酸性粒细胞Key words
wheezing bronchitis/asthma/fractional exhaled nitric oxide/eosinophils分类
医药卫生引用本文复制引用
李东丽,陈斐斐,孟扬琴..FeNO、EOS与喘息性支气管炎患儿肺功能的相关性及对哮喘的预测价值[J].中国现代医学杂志,2023,33(23):22-27,6.基金项目
湖北省自然科学基金(No:2020CFB359) （No:2020CFB359）
