中国现代医学杂志2023，Vol.33Issue(23)：47-51,5.DOI:10.3969/j.issn.1005-8982.2023.23.009
特发性中枢性性早熟女童FGF23、Klotho、IGF-1和性激素水平分析
Analysis of FGF23,Klotho,IGF-1 and sex hormone levels in girls with central precocious puberty
摘要
Abstract
Objective To detect the levels of serum fibroblast growth factor 23(FGF23),Klotho,insulin-like growth factor-1(IGF-1),and gonadotropins in girls with idiopathic central precocious puberty(ICPP)and explore their relationship with ICPP.Methods Thirty-four girls diagnosed with ICPP,aged＜8 years,treated at the Department of Pediatrics,Hebei Provincial People's Hospital,from June 2021 to June 2022,were selected as the observation group.Twenty-six healthy girls aged＜8 years who underwent health examinations during the same period and had not initiated puberty were selected as the control group.Serum levels of FGF23,Klotho,IGF-1,sex hormones,bone age,and ovarian volume were measured in all participants,and the results were compared and analyzed.Results There were statistically significant differences in height,height standard deviation score,body mass index,body mass index standard deviation score,bone age,bone age index,and ovarian volume between the observation group and the control group(P＜0.05).The levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),and FGF23 were significantly different between the observation group and the control group(P＜0.05).In the observation group,Klotho and FGF23 were positively correlated(r=0.781,P＜0.05),and Klotho was positively correlated with IGF-1,LH,body mass index,bone age,and ovarian volume(r=0.646,0.520,0.317,0.413,and 0.697,respectively;all P＜0.05).FGF23 was positively correlated with IGF-1,LH,body mass index,bone age,and ovarian volume(r=0.781,0.591,0.392,0.353,0.410,and 0.669,respectively;all P＜0.05).Conclusion Serum IGF-1,FGF23,and Klotho play certain physiological roles in the pubertal development of girls.关键词
特发性中枢性性早熟/成纤维细胞生长因子23/Klotho/胰岛素样生长因子Key words
idiopathic central precocious puberty/fibroblast growth factor 23/klotho/insulin-like growth factor-1分类
医药卫生引用本文复制引用
刘钰萍,孙萌,周冉,李蒙蒙,程亚颖..特发性中枢性性早熟女童FGF23、Klotho、IGF-1和性激素水平分析[J].中国现代医学杂志,2023,33(23):47-51,5.基金项目
河北省重点研发计划项目卫生健康创新专项(No:21377783D) （No:21377783D）
2019年度河北省医学科学研究课题计划(No:20190296) （No:20190296）
