中国药房2023，Vol.34Issue(24)：3012-3019,8.DOI:10.6039/j.issn.1001-0408.2023.24.10
全球血友病患者健康效用值的系统综述与Meta分析
Systematic review and meta-analysis of health state utility for global patients with hemophilia
摘要
Abstract
OBJECTIVE To systematically sort out and evaluate the health state utility of hemophiliac patients,and to provide reliable parameters for conducting pharmacoeconomic evaluation and health technology assessment.METHODS Retrieved from CNKI,Wanfang data,VIP,CBM,PubMed,Embase,the Cochrane Library,Scopus and Web of Science databases,relevant literature about the measurement of health state utility in hemophiliac patients was collected from the inception to February 2023.After screening literature,extracting data and evaluating the quality of literature,meta-analysis was performed for health state utility with Stata 15.1 software.RESULTS Thirty-eight papers were finally included,with the highest and lowest health utility values of 0.90 and 0.46,respectively.Those studies mostly adopted the EuroQol Five Dimensions Questionnaire(EQ-5D)(73.7%).Results of meta-analysis showed that health state utility of global hemophiliac patients was 0.69,95%confidence interval was 0.65-0.74;those of patients with mild,moderate and severe hemophilia were 0.79,0.70,and 0.64,respectively;health state utility for patients with inhibitors(0.64)was lower than that of patients without inhibitors(0.69);health state utility for the Chinese patient population was 0.55,which was higher than that of Iranian patients(0.46),but lower than those of other developed countries.CONCLUSIONS There is some heterogeneity in the results of the studies across countries/regions,with higher health state utility in developed countries than in developing countries.As the severity of hemophilia increases,the trend of decreasing health state utility is obvious.关键词
罕见病/血友病/健康效用值/系统评价/Meta分析Key words
rare diseases/hemophilia/health state utility/systematic evaluation/meta-analysis分类
医药卫生引用本文复制引用
冯俊超,李顺平,房云海,史钊..全球血友病患者健康效用值的系统综述与Meta分析[J].中国药房,2023,34(24):3012-3019,8.基金项目
国家自然科学基金面上项目(No.72174110) （No.72174110）
