中国药房2023，Vol.34Issue(24)：3025-3029,5.DOI:10.6039/j.issn.1001-0408.2023.24.12
泊沙康唑口服混悬液在HSCT患者中的剂量校正浓度及其影响因素分析
Dose-adjusted concentrations of Posaconazole oral suspension in hematopoietic stem cell transplantation patients and analysis of the influential factors
摘要
Abstract
OBJECTIVE To analyze the dose-adjusted concentrations of Posaconazole oral suspension in patients undergoing hematopoietic stem cell transplantation(HSCT)and their influential factors.METHODS Data were collected from hospitalized HSCT patients admitted to the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)from January 2021 to April 2023 who took Posaconazole oral suspension for the prevention of invasive fungal disease(IFD)and received blood concentration of posaconazole.The rate of concentration attainment and clinical failure rate of posaconazole for the prevention of IFD were evaluated,and one-way and multiple linear regression analyses were performed for the influential factors of dose-adjusted concentrations(C0/D)of posaconazole.RESULTS A total of 44 patients were enrolled;the mean C0 of posaconazole in patients was(0.99±0.94)µg/mL,and 20 patients had a C0≥0.7 μg/mL,with a concentration attainment rate of 45.45%for the prevention of IFD;13 cases were clinical failures,with a clinical failure rate of 29.55%.Of 24 patients who did not achieve C0/D of posaconazole for IFD prophylaxis,one patient was a clinical failure despite timely dose adjustment of posaconazole in seven patients;seven of the thirteen patients who did not undergo dose adjustment were clinical failures;and the remaining four patients were switched to other antifungal agents.The results of univariate analysis showed that gender,body mass index(BMI),renal function,combined use of sodium phenytoin,omeprazole and metoclopramide had a significant effect on the C0/D of posaconazole(P＜0.05);the results of multivariate linear regression analysis showed that gender,BMI and combined use of sodium phenytoin were the independent factors affecting the C0/D of posaconazole(P＜0.05).CONCLUSIONS Significant individual differences are reflected in the blood concentration of Posaconazole oral suspension;gender,BMI and combined use of sodium phenytoin are independent factors affecting the C0/D of posaconazole.关键词
泊沙康唑/剂量校正浓度/影响因素/造血干细胞移植/治疗药物监测Key words
posaconazole/dose-adjusted concentration/influential factor/hematopoietic stem cell transplantation/therapeutic drug monitoring分类
医药卫生引用本文复制引用
董琳,张潇月,李雪,林子云,穆锴,杨依磊,时海燕,王红美,束一朔,董中华,衣巧艳,李洪娟,顾艳,韩燕,丁国玉,赵羽琦..泊沙康唑口服混悬液在HSCT患者中的剂量校正浓度及其影响因素分析[J].中国药房,2023,34(24):3025-3029,5.基金项目
国家重点研发计划项目(No.2020YFC2008303,No.2020YFC2008306) （No.2020YFC2008303,No.2020YFC2008306）
