中国药房2023，Vol.34Issue(24)：3046-3050,5.DOI:10.6039/j.issn.1001-0408.2023.24.16
不同肠内营养制剂用于重症急性胰腺炎的疗效及胃肠道耐受性研究
Efficacy of different enteral nutrition drugs for severe acute pancreatitis and their gastrointestinal tolerance
摘要
Abstract
OBJECTIVE To compare the efficacy of different enteral nutrition(EN)drugs for severe acute pancreatitis(SAP)and their gastrointestinal tolerance.METHODS A total of 118 SAP patients admitted to the Pancreatic Center of Jiangsu Provincial People's Hospital from January 1,2022 to June 30,2023 were collected and divided into short-peptide EN drugs(SP)group(41 cases),dietary fiber-free intact protein EN drugs(TP-MCT)group(40 cases)and dietary fiber-containing intact protein EN drugs(TPF-DM)group(37 cases)according to the types of EN.All three groups of patients were given continuous pumps of EN drugs via nasal feeding for 24 hours,with a target energy dose of 25-30 kcal/kg.The blood nutritional indexes[albumin(ALB),total protein(TP),hemoglobin(Hb),globulin(GLB)],inflammation indexes[white blood cells(WBC),percentage of neutrophils(N%),procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)],clinical outcomes indexes[time of stay in the intensive care unit(ICU),length of hospital stay,duration of resuming oral diet,the rate of cases without improvement,mortality rate]and the occurrence of gastrointestinal tolerance were collected from 3 groups before medication and 7 d after medication.RESULTS After treatment,ALB and TP in 3 groups were significantly higher than before treatment(P＜0.05);CRP and N%of 3 groups,PCT of TP-MCT group and IL-6 of SP group were significantly lower than corresponding group before medication(P＜0.05);PCT of TP-MCT group and IL-6 of SP group were significantly lower than those of other two groups at corresponding period(P＜0.05).There were no statistical significances in ALB,TP,CRP or N%among the three groups after medication,and in Hb,GLB or WBC among the three groups before and after treatment(P＞0.05).There was no significant difference in clinical outcome indexes among 3 groups(P＞0.05).The incidence of gastrointestinal adverse reactions in the TP-MCT group was the lowest(32.50%),and significantly lower than those in the SP group(46.34%)and TPF-DM group(48.65%)(P＜0.05).CONCLUSIONS Different EN preparations can improve the nutritional status and reduce the inflammatory response in SAP patients to different extents,among which SP and TP-MCT are more effective,and TP-MCT shows the better gastrointestinal tolerance.关键词
肠内营养/重症急性胰腺炎/疗效/耐受性/不良反应Key words
enteral nutrition/severe acute pancreatitis/therapeutic efficacy/tolerance/adverse reaction分类
医药卫生引用本文复制引用
陈旭,邓毅,李强,吴迪..不同肠内营养制剂用于重症急性胰腺炎的疗效及胃肠道耐受性研究[J].中国药房,2023,34(24):3046-3050,5.基金项目
江苏省药学会-奥赛康医院药学基金(No.A202101) （No.A202101）
