中国医科大学学报2023，Vol.52Issue(12)：1074-1081,8.DOI:10.12007/j.issn.0258-4646.2023.11.004
原发性睾丸弥漫大B细胞淋巴瘤的临床特征与预后分析
Clinical characteristics and prognosis of primary testicular diffuse large B-cell lymphoma
摘要
Abstract
Objective To investigate the clinical characteristics and prognosis of primary testicular diffuse large B-cell lymphoma(PT-DLBCL).Methods The clinical data,treatment regimen and prognosis of PT-DLBCL patients were analyzed retrospectively,from the records of the Affiliated Hospital of Nantong University and the Second Affiliated Hospital of Dalian Medical University from Jan.1,2000 to Dec.31,2022.Results The median age of the 47 PT-DLBCL patients was 64 years old.The median overall survival(OS)was 41.6 months,with 1-year,3-year,and 5-year PT-DLBCL OS of 93%,77%,and 59%,respectively.Kaplan-Meier univariate analysis demonstrated that a diagnosed age≥70 years,Eastern cooperative oncology group(ECOG)score≥3,international prognostic index(IPI)score≥4,no combination of anthracycline and rituximab,a single treatment regimen,ineffective initial treatment and relapse,were asso-ciated with an adverse prognosis in PT-DLBCL(all P<0.05).Multivariate Cox regression analysis showed that an ECOG score≥3,no application of Rituximab,and an ineffective initial treatment response were independent risk factors for the poor prognosis of PT-DLBCL(all P<0.05).Conclusion PT-DLBCL is rare and associated with a poor prognosis.Early diagnosis and therapy with a combination of anthracyclines and rituximab may improve outcomes.关键词
原发性睾丸淋巴瘤/弥漫大B细胞淋巴瘤/临床特征/预后Key words
primary testicular lymphoma/diffuse large B-cell lymphoma/clinical characteristics/prognosis分类
医药卫生引用本文复制引用
礼仕可,施文瑜,张卓,张锋,孙秀华..原发性睾丸弥漫大B细胞淋巴瘤的临床特征与预后分析[J].中国医科大学学报,2023,52(12):1074-1081,8.基金项目
吴阶平医学基金会临床科研专项资助基金(320.6750.2021-02-56) （320.6750.2021-02-56）
