中国医科大学学报2023，Vol.52Issue(12)：1082-1086,5.DOI:10.12007/j.issn.0258-4646.2023.12.005
食管癌患者外周血中白细胞介素-1β和组织中程序性死亡分子1的表达对预后的影响及临床意义
The expression of IL-1β in peripheral blood and PD-1 in tissue and its influence on the prognosis of patients with esophageal cancer and its clinical significance
摘要
Abstract
Objective To detect the expressions of interleukin-1β(IL-1β)in peripheral blood and programmed death molecule 1(PD-1)in esophageal cancer tissues and to analyze their influence on clinicopathological features and prognosis of patients.Methods A total of 127 patients with esophageal cancer who underwent surgical treatment at the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to May 2020 were collected and divided into two groups:the survival group(n= 95)and the death group(n= 32),based on their survival status 3 years after surgery.Clinical data of the patients were collected.The expressions of PD-1 and programmed death ligand 1(PD-L1)in esophageal cancer tissues were detected through immunohistochemistry,while the levels of IL-6,IL-1β,and tumor necrosis factor-α(TNF-α)in peripheral blood were measured using enzyme-linked immunosorbent assay(ELISA).Cox regression analysis was performed to identify the risk factors for death 3 years after surgery.The 3-year Kaplan-Meier survival curves of patients with different expressions of IL-1βand PD-1 were plotted,and the survival rates among the three groups were compared using the log-rank test.Results In the death group,the proportions of patients with age≥60 years old,lymph node metastasis,infiltration into the muscle layer,tumor diameter>3 cm,IL-1β high level,TNF-αhigh level,and PD-1 positive expression were higher than those in the survival group.Conversely,the proportions of patients with high IL-6 levels were lower than those in the survival group,with statistically significant differences between the groups(P<0.05).Infiltration into the myometrium,tumor diameter>3 cm,high IL-1β level,and PD-1 positive expression were identified as independent risk factors for postoperative death.The 3-year survival rates were 92.4%,13.3%,and 84.2%for patients in the normal IL-1β+PD-1 negative group,high IL-1β+PD-1 positive group,and normal IL-1β+PD-1 positive group/high IL-1β+PD-1 negative group,respectively.Significant differences existed between the groups(χ2=82.318,P<0.01),with the highest survival rate observed in the normal IL-1β+ PD-1 negative group and the lowest in the high IL-1β+ PD-1 positive group.Conclusion Positive expression of PD-1 and a high level of IL-1βwere identified as independent risk factors for death in patients with esophageal cancer.Notably,patients with positive expression of PD-1+high levels of IL-1βexhibited a low survival rate.关键词
食管癌/肿瘤微环境/白细胞介素-1β/程序性死亡1受体Key words
esophageal cancer/tumor microenvironment/interleukin-1β/programmed death 1 receptor分类
医药卫生引用本文复制引用
王献,尚自强,杨冬,杨惠..食管癌患者外周血中白细胞介素-1β和组织中程序性死亡分子1的表达对预后的影响及临床意义[J].中国医科大学学报,2023,52(12):1082-1086,5.基金项目
河南省医学科技攻关计划联合共建立项项目(LHGJ20200023) （LHGJ20200023）
