中国医科大学学报2023，Vol.52Issue(12)：1087-1091,5.DOI:10.12007/j.issn.0258-4646.2023.12.006
125I粒子植入在原发性肺癌治疗后复发患者中的近期和远期疗效及影响因素
Short-and long-term efficacy and influencing factors of 125I seed implantation for relapsed primary lung cancer
摘要
Abstract
Objective To analyze the short-and long-term efficacy and influencing factors of 125I seed implantation for relapsed primary lung cancer.Methods Forty patients who received 125I seed implantation for relapsed primary lung cancer were retrospectively included.CT examination was performed 3 months after surgery to evaluate the short-term efficacy.Patients were divided into the effective group(complete remission and partial remission)or the ineffective group(stable disease and progressive disease).Patient deaths and survival times were documented through telephone or electronic case inquiry.Factors influencing short-term efficacy and long-term survival were evaluated using logistic and Cox regression analysis,respectively.Results Among the 40 patients,16 cases were effective and 24 were ineffective.Multivariate logistic regression analysis indicated that postoperative dose delivered to 100%gross tumor volume(D100)(OR= 0.944,95%CI:0.898-0.992,P= 0.023)was an independent factor for short-term efficacy.The median duration of follow-up was 12 months.Twenty-five patients died,ten survived,and five were lost to follow-up.Multivariate Cox regression analysis suggested that the longest tumor diameter(HR= 1.310,95%CI:1.010-1.698,P= 0.042)was an independent factor for long-term survival.Conclusion 125I seed implantation has improved the short-and long-term efficacy of treatment for relapsed primary lung cancer.Postoperative D100 is an independent factor influencing short-term efficacy,and longest tumor diameter is an independent factor for long-term survival,in patients receiving 125I seed implantation for relapsed primary lung cancer.关键词
原发性肺癌/125I放射性粒子/近距离放射治疗/近期疗效/生存分析/影响因素Key words
primary lung cancer/125I radioactive particles/brachytherapy/short-term efficacy/survival analysis/influencing factor分类
医药卫生引用本文复制引用
王诗彤,王永槐,王若雨,王喆,马春燕..125I粒子植入在原发性肺癌治疗后复发患者中的近期和远期疗效及影响因素[J].中国医科大学学报,2023,52(12):1087-1091,5.基金项目
辽宁省科学技术计划项目(2021JH1/10400051) （2021JH1/10400051）
