中国医科大学学报2023，Vol.52Issue(12)：1106-1112,1118,8.DOI:10.12007/j.issn.0258-4646.2023.12.009
CD276在泛癌中的免疫表达及预后
CD276 immune expression and prognosis in pan-cancer
摘要
Abstract
Objective To investigate the expression of CD276 in pan-cancer,its effect on patient prognosis,and its mechanism of action.Methods TCGA and GTEx databases were used to study the differential expression of CD276 in tumor and normal tissues;R language was used to analyze the effects of CD276 on the prognosis of patients with pan-cancer,the tumor microenvironment,the tumor mutation burden,and microsatellite instability;the correlation between the expression of CD276 in tumor tissues and the tumor immune cell infil-tration was further examined;the biological function of CD276 was analyzed using Gene Set Enrichment Analysis(GSEA);and finally,real-time PCR was used to validate the expression of CD276 in tumors in vitro.Results A statistical difference in CD276 expression was detected between tumor and normal tissues(P<0.05).CD276 affects tumor prognosis and is strongly associated with the tumor microenvi-ronment,tumor mutational burden,microsatellite instability,and tumor immune cell infiltration.Conclusion Comprehensive pan-cancer analysis identified CD276 as a biomarker for immune infiltration and poor cancer prognosis,which can be used as a novel immunomodula-tory target for the development of immunotherapeutically-targeted drugs,providing new ideas for tumor therapy.关键词
CD276/肿瘤微环境/免疫/预后/泛癌Key words
CD276/tumor microenvironment/immunity/prognosis/pan-cancer分类
医药卫生引用本文复制引用
张癸乾,王宁,荣耀,唐明政,蔡辉..CD276在泛癌中的免疫表达及预后[J].中国医科大学学报,2023,52(12):1106-1112,1118,8.基金项目
2021年中央引导地方科技发展基金(ZYYDDFFZZJ-1) （ZYYDDFFZZJ-1）
甘肃省人民医院优秀硕博士基金(22GSSYD-19) （22GSSYD-19）
甘肃省人民医院科技创新平台基金重点项目(21gssya-4) （21gssya-4）
