中国药理学与毒理学杂志2023，Vol.37Issue(12)：885-894,10.DOI:10.3867/j.issn.1000-3002.2023.12.001
神经血管单元结构和功能及其在脑缺血损伤发生机制中的作用
Structure and function of neurovascular unit and its role in pathogenesis of cerebral ischemia injuries
摘要
Abstract
In recent years,increasing attention has been paid to the study on the pathogenesis of cerebral ischemia in terms of the overall structure and function of neurovascular unit(NVU),which has become one of the hot spots in the field of brain sciences and major brain diseases.This paper is intended to outline the roles of the four main NVU cells(neurons,astrocytes,microglia and cerebral microvascular endothelial cells)in brain function and pathogenesis of cerebral ischemia,which are closely related in structure,work together to maintain cerebral homeostasis in function,and play an important role in brain function and cerebral ischemic injuries.NVU injury leads to microvascular and blood brain barrier integrity impairment,neuronal cell death,glial reaction and immune cell infiltration,and even tissue injury and brain edema.This paper also aims to elucidate the roles of NVU structure and function in the pathogenesis of cerebral ischemia,and offer new ideas and strategies for the research related to drugs for prevention and treatment of cerebral ischemia based on NVU structure and function.关键词
神经血管单元/结构和功能/脑缺血/发病机制Key words
neurovascular unit/structure and function/cerebral ischemia/pathogenesis分类
医药卫生引用本文复制引用
马贺远,李钦青,楚世峰,张钊,贺文彬..神经血管单元结构和功能及其在脑缺血损伤发生机制中的作用[J].中国药理学与毒理学杂志,2023,37(12):885-894,10.基金项目
国家自然科学基金(U21A20410) （U21A20410）
山西省重点研发计划(国际科技合作)重大区域创新合作项目(201903D421018) （国际科技合作）
山西省重点研发计划(国际科技合作)重大区域创新合作项目(201803D421006) National Natural Science Foundation of China(U21A20410) （国际科技合作）
Focus on Research and Development Program(International Technology Cooperation)in Shanxi Province Major Regional Innovation Cooperation Projects(201903D421018) （International Technology Cooperation）
and Focus on Research and Development Program(International Technology Cooperation)in Shanxi Province Major Regional Innovation Cooperation Projects(201803D421006) （International Technology Cooperation）
