中国药理学与毒理学杂志2023，Vol.37Issue(12)：936-950,15.DOI:10.3867/j.issn.1000-3002.2023.12.007
纳米药物在缺血性脑卒中靶向治疗中的研究进展
Research progress in nanomedicine for targeted therapy of ischemic stroke
摘要
Abstract
In case of ischemic stroke(IS),thrombus in the vascular system can cause ischemia and hypoxia in brain tissue,produce inflammatory cytokines and cause brain tissue damage,while reactive oxygen species during ischemia-reperfusion cause stress injury.Conventional drug administra-tion is limited by the selective permeability of the blood-brain barrier and the low bioavailability of the drug itself,and its therapeutic effect against IS is unsatisfactory.Nanomedicine is expected to bring hope in that it has a unique mechanism of action and can cross the blood-brain barrier to reach the periphery of the infarct,release drugs or therapeutic genes,and exert a therapeutic effect.Nanomedi-cine inhibits platelet aggregation,enhances the efficacy of thrombolytic drugs,dissolves thrombus,increases blood supply to ischemic areas,eliminates reactive oxygen species and weakens injury response by fighting inflammatory cytokines.Loaded therapeutic genes regulate the differentiation pro-cess of neural stem cells,increase the number of neurons,induce the occurrence of blood vessels,and enhance the repair function of brain tissue.Nanomedicines can not only improve pharmacokinetics and pharmacodynamics to achieve more effective drug treatment,but also use nanoimaging technology to achieve real-time monitoring and condition assessment of therapy.关键词
缺血性脑卒中/纳米药物/靶向治疗Key words
ischemic stroke/nanomedicine/targeted therapy分类
医药卫生引用本文复制引用
张敏娜,唐仁明,袁丽丽,钟鸣,王光辉..纳米药物在缺血性脑卒中靶向治疗中的研究进展[J].中国药理学与毒理学杂志,2023,37(12):936-950,15.基金项目
山东省中医药科技发展计划(20190453) Traditional Chinese Medicine Science&Technology Development Plan of Shandong Province(20190453) （20190453）
