中国药物经济学2023，Vol.18Issue(11)：11-16,6.DOI:10.12010/j.issn.1673-5846.2023.11.002
肝爽颗粒治疗慢性乙型肝炎肝硬化失代偿期的有效性与安全性及经济性
Efficacy,Safety and Economic Analysis of Ganshuang Granule in the Treatment of Decompensated Stage of Chronic Hepatitis B Cirrhosis
摘要
Abstract
Objective To explore the efficacy,safety and economy of Ganshuang granules in the treatment of decompensated stage of chronic hepatitis B cirrhosis.Methods Based on the data from the establishment of HIS system in a Class Ⅲ hospital in Beijing from June 30,2018,the patients meeting the requirements were screened according to the inclusion and exclusion criteria for decompensation of chronic hepatitis B cirrhosis,and were divided into observation group(Ganshuang Granules)with 103 cases and control group(compound Biejia Ruangan tablets)with 24 cases according to different drug use.Imaging parameters(splenic intercostal thickness,splenic length,portal diameter),blood biochemical parameters(albumin(ALB),globulin(GLB),direct bilirubin(DBIL),total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),glutamyl transfer)enzyme(GGT),cholinesterase(CHE)and liver fibrosis indexes(hyaluronic acid(HA),laminin(LN),type IV collagen(CLIV),type Ⅲ precollagen(PCⅢ))of the two groups were observed,and the safety of the two groups was observed,and the economy was analyzed by cost-effectiveness analysis.Results There was no significant difference in the imaging indexes(spleen intercostal thickness,spleen length diameter and portal vein diameter)between the two groups before and after treatment(P＞0.05).The effect of CHE increased in the observation group was better than that in the control group(P＜0.05),but there was no significant difference in other indicators among the groups(P＞0.05).The change of HA before and after treatment in the observation group was greater than that in the control group(P＜0.05).There was no significant difference in LN,CLⅣ and PCⅢ between the two groups compared with before treatment(P＞0.05),and there was no significant difference between the two groups(P＞0.05).There was no significant difference in ALT normality between the two groups(P＞0.05).No obvious adverse reactions were observed in both groups.In terms of economy,CHE index,C/E in the observation group was lower than that in the control group(59.45 vs.115.94),ICER value was 12.20,and the observation group was a cost-effectiveness ratio advantage scheme.In terms of HA index,C/E in the observation group was lower than that in the control group(226.37 vs.1 275.18),ICER value was 30.02,and the observation group was a cost-effectiveness ratio advantage scheme.Sensitivity analysis shows that the basic analysis results are robust.Conclusion Compared with compound Biejia Ruangan tablets,Ganshuang granules were more effective in treating decompensated stage of chronic hepatitis B cirrhosis,and had significant anti-fibrosis effect,and it is a pharmacoeconomic treatment scheme with advantages in clinical treatment.关键词
慢性乙型肝炎/肝硬化/失代偿期/肝爽颗粒/有效性/安全性/经济性Key words
Chronic hepatitis B/Cirrhosis of the liver/Decompensation period/Ganshuang granule/Effectiveness/Security/Economy分类
医药卫生引用本文复制引用
张欣颖,王葳,卢斯琪,周佳孟,周平达,徐龙辰,魏嘉茵,朱文涛..肝爽颗粒治疗慢性乙型肝炎肝硬化失代偿期的有效性与安全性及经济性[J].中国药物经济学,2023,18(11):11-16,6.基金项目
中央高校基本科研业务专项(2020-JYB-ZDGG-072) （2020-JYB-ZDGG-072）
