中国药物经济学2023，Vol.18Issue(11)：21-26,31,7.DOI:10.12010/j.issn.1673-5846.2023.11.004
3种第二代抗组胺药治疗儿童过敏性鼻炎的成本-效果
Cost-Effectiveness of Three Second-generation Antihistamines in the Treatment of Allergic Rhinitis in Children
摘要
Abstract
Objective To analyze the cost-effectiveness of loratadine,cetirizine and levocetirizine second-generation antihistamines in the treatment of allergic rhinitis in children by pharmacoeconomic evaluation,and to provide references and suggestions for the clinical treatment of allergic rhinitis in children.Methods The efficacy index was obtained by single group rate meta-analysis,and the cost-effectiveness analysis of 3 second-generation antihistamine drugs in the treatment of allergic rhinitis in children was conducted through the drug bidding and procurement platform of Shandong Province,combined with the cost of drugs obtained by the dosage and course of treatment of children at different ages.The single factor sensitivity analysis,probability sensitivity analysis and scenario hypothesis analysis based on drug cost change were also carried out.Results For the treatment of allergic rhinitis in children aged 2 to 6 years,loratat was excluded as an absolute disadvantage,the incremental cost-effectiveness ratio(ICER)of cetirizine compared with levocetirizine was 19.34 yuan.For the treatment of allergic rhinitis in children aged 6 to 11 years,loratat was excluded as an absolute disadvantage scheme,and the ICER of cetirizine was 38.69 yuan compared with levocetirizine.For the treatment of allergic rhinitis in children≥12 years old,the higher cost of levocetirizine and loratadine was excluded as the absolute disadvantage,and cetirizine was the advantage.The results of sensitivity analysis were basically consistent with those of basic analysis.Conclusion The second-generation antihistamine is an absolute disadvantage in the treatment of allergic rhinitis in children of all ages.In the clinical treatment of allergic rhinitis in children aged 2 to 11 years,the optimal plan can be selected according to the patient's willingness to pay(WTP)threshold.If WTP is lower than ICER,levocetirizine is preferred;if WTP is higher than ICER,cetirizine is preferred.Cetirizine is an absolute advantage in the clinical treatment of allergic rhinitis in children≥12 years old.关键词
第二代抗组胺药/儿童过敏性鼻炎/成本-效果分析/增量成本-效果比Key words
Second-generation antihistamines/Children allergic rhinitis/Cost-effectiveness analysis/Incremental cost-effectiveness ratio分类
医药卫生引用本文复制引用
莫晓媚,李国菊,赵荣达,赵娜,徐鲁杰,刘青,陈文静,闫美兴..3种第二代抗组胺药治疗儿童过敏性鼻炎的成本-效果[J].中国药物经济学,2023,18(11):21-26,31,7.基金项目
中国药学会全国医药信息网2022年科普研究重点项目(CMEI2022KPYJ001106) （CMEI2022KPYJ001106）
青岛市市级临床重点专科建设项目(2022-2024-77) （2022-2024-77）
北京医药卫生经济研究会资助项目(2020-9-9) （2020-9-9）
