摘要
Abstract
Objective To explore the effect of budesonide combined with amoxicillin and clavulanate potassium on improving pulmonary function and inflammation in children with pneumonia.Methods Seventy children with pneumonia treated in Ruijin People's Hospital from March 2021 to March 2022 were selected as the study objects,and were divided into conventional group and experimental group according to different treatment methods,with 35 cases in each group.The conventional group was given amoxicillin and clavulanate potassium treatment,and the experimental group was given budesonide and amoxicillin and clavulanate potassium combined treatment.The time for clinical symptoms to disappear and the changes of lung function,inflammatory index and immune function index before and after treatment were compared between the two groups.Results The disappearance time of pulmonary rales,fever,asthma,cough and expectoration in experimental group was significantly shorter than that in conventional group(P＜0.05).There was no significant difference in lung function index between the two groups before treatment(P＞0.05).After treatment,the peak expiratory flow rate(PEF),forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)of the two groups were significantly increased,and the improvement of PEF,FVC and FEV1 of the experimental group was more obvious,with statistical significance(P＜0.05).There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P＞0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),neutrophil to lymphocyte ratio(NLR)and procalcitonin(PCT)in 2 groups were significantly decreased,and the decrease in experimental group was greater,with statistical significance(P＜0.05).There was no significant difference in the level of immune function indexes between the two groups before treatment(P＞0.05).After treatment,the levels of CD3+ and CD8+ in both关键词
布地奈德/阿莫西林克拉维酸钾/肺炎患儿/肺功能/炎症指标Key words
Budesonide/Amoxicillin clavulanate potassium/Children with pneumonia/Lung function/Inflammatory index分类
临床医学
