中国医学创新2023，Vol.20Issue(34)：45-49,5.DOI:10.3969/j.issn.1674-4985.2023.34.010
右美托咪定在小儿腹股沟疝手术中的应用效果及对氧化应激及血流动力学的影响
Application Effect of Dexmedetomidine in Pediatric Inguinal Hernia Surgery and Its Effects of Oxidative Stress and Hemodynamics
摘要
Abstract
Objective:To investigate the effect of Dexmedetomidine in pediatric inguinal hernia surgery and its effects of oxidative stress and hemodynamics.Method:A total of 108 children who underwent inguinal hernia surgery in Zhongxiang TCM Hospital from January 2021 to January 2022 were selected and divided into the observation group(54 cases)and the control group(54 cases)according to the random number table method.The control group received intravenous infusion of 0.9% Sodium Chloride Injection after anesthesia induction during the surgery,and the observation group received intravenous infusion of Dexmedetomidine after anesthesia induction.The systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),superoxide dismutase(SOD),malondialdehyde(MDA)and Ramsay sedation scores of the two groups were compared before anesthesia(T0),after pneumoperitoneum establishment(T1),20 minutes after surgery(T2)and after extubation(T3),the adverse reactions of the two groups during treatment were recorded.Result:The differences in SBP,DBP and HR between the two groups at T0 were not statistically significant(P>0.05);at T1,T2 and T3,the above indexes in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in SOD and MDA between the two groups at T0(P>0.05);at T1,T2 and T3,the above indexes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The difference in Ramsay sedation score at T0 was not statistically significant between the two groups(P>0.05);at T1,T2 and T3,the Ramsay sedation scores of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group(3.70%)was lower than that in the control group(14.81%),the difference was statistically significant(P<0.05).Conclusion:Dexmedetomidine can maintain the hemodynamics stability of children with inguinal hernia surgery,reduce oxidative stress,calm good effect,less adverse reactions and high safety.关键词
右美托咪定/腹股沟疝手术/儿童/血流动力学/氧化应激/不良反应Key words
Dexmedetomidine/Inguinal hernia surgery/Children/Hemodynamics/Oxidative stress/Adverse reactions引用本文复制引用
刘小琴..右美托咪定在小儿腹股沟疝手术中的应用效果及对氧化应激及血流动力学的影响[J].中国医学创新,2023,20(34):45-49,5.基金项目
湖北省卫生计生委科技计划项目(20197523) （20197523）
